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(DES oh nide)

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Cream, External:

DesOwen: 0.05% (60 g)

Generic: 0.05% (15 g, 60 g)

Foam, External:

Verdeso: 0.05% (50 g [DSC], 100 g) [contains cetyl alcohol, propylene glycol]

Gel, External:

Desonate: 0.05% (60 g) [contains edetate disodium dihydrate, methylparaben, propylene glycol, propylparaben]

Kit, External:

DesOwen Cream w/Cetaphil Lot: 0.05% [DSC] [contains benzyl alcohol, propylene glycol]

DesOwen Lot w/Cetaphil Cream: 0.05% [DSC] [contains benzyl alcohol, cetyl alcohol, edetate sodium (tetrasodium), methylparaben, peg-30 glyceryl stearate, propylene glycol, propylparaben]

DesOwen Oint w/Cetaphil Lot: 0.05% [DSC] [contains benzyl alcohol]

Lotion, External:

DesOwen: 0.05% (59 mL, 118 mL) [contains cetyl alcohol, edetate disodium, methylparaben, propylene glycol, propylparaben]

LoKara: 0.05% (59 mL, 118 mL)

Generic: 0.05% (59 mL, 118 mL)

Ointment, External:

DesOwen: 0.05% (60 g [DSC])

Generic: 0.05% (15 g, 60 g)

Brand Names: U.S.

  • Desonate
  • DesOwen
  • DesOwen Cream w/Cetaphil Lot [DSC]
  • DesOwen Lot w/Cetaphil Cream [DSC]
  • DesOwen Oint w/Cetaphil Lot [DSC]
  • LoKara
  • Verdeso

Pharmacologic Category

  • Corticosteroid, Topical


Topical corticosteroids have anti-inflammatory, antipruritic, and vasoconstrictive properties. May depress the formation, release, and activity of endogenous chemical mediators of inflammation (kinins, histamine, liposomal enzymes, prostaglandins) through the induction of phospholipase A2 inhibitory proteins (lipocortins) and sequential inhibition of the release of arachidonic acid. Desonide has low range potency.


Dependent on formulation, amount applied and nature of skin at application site; may be increased with inflammation or occlusion




Primarily urine; bile

Use: Labeled Indications

Atopic dermatitis (foam and gel): Treatment of mild to moderate atopic dermatitis in patients 3 months and older

Corticosteroid-responsive dermatoses (cream, ointment, and lotion): Relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.


Hypersensitivity to desonide or any component of the formulation.

Verdeso: There are no contraindications listed in the manufacturer's labeling.

Documentation of allergenic cross-reactivity corticosteroids is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.

Dosing: Adult

Atopic dermatitis: Topical: Foam, gel: Apply 2 times daily sparingly. Therapy should be discontinued when control is achieved. If no improvement is seen within 4 weeks, reassessment of diagnosis may be necessary; treatment should not exceed 4 consecutive weeks.

Corticosteroid responsive dermatoses: Topical: Cream, ointment, lotion: Apply 2 to 3 times daily sparingly. Therapy should be discontinued when control is achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Atopic dermatitis: Infants ≥3 months, Children, and Adolescents: Foam, gel: Refer to adult dosing.

Dosing: Renal Impairment

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment

There are no dosage adjustments provided in the manufacturer's labeling.


For topical use only; not for oral, ophthalmic, or intravaginal use. For use on the face, dispense desonide in hands and gently massage into affected areas of the face; for areas other than the face, desonide may be dispensed directly on the affected area. Wash hands after use (unless hands are part of the treatment area). Do not use on open wounds; apply sparingly using smallest amount needed to adequately cover the affected area. Use of occlusive dressings is not recommended; do not use in the treatment of diaper dermatitis. Avoid contact with eyes or other mucous membranes.

Foam, lotion: Shake well before use. Foam is flammable; patients should not smoke during or immediately following application.

Gel: Should not be used on the underarm or groin areas of pediatric patients.


Cream, lotion, ointment: Store between 2°C and 30°C (36°F and 86°F).

Foam: Store between 20°C and 25°C (68°F and 77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F). Foam is flammable; keep away from excessive heat (eg, temperatures >49°C [120°F], fire or flames. Do not puncture or incinerate container.

Gel: Store at 25°C (77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F).

Drug Interactions

Ceritinib: Corticosteroids may enhance the hyperglycemic effect of Ceritinib. Monitor therapy

Adverse Reactions

Frequency not defined.

Cardiovascular: Hypertension

Central nervous system: Headache, irritability

Dermatologic: Erythema (transient, intense), exfoliation of skin, pruritus, skin rash, telangiectasia, xeroderma

Endocrine & metabolic: HPA-axis suppression, hyperglycemia

Infection: Increased susceptibility to infection

Local: Application site: Atrophic striae, dermatitis, dyschromia, local irritation, local pruritus, localized burning, skin atrophy, stinging of the skin

Respiratory: Asthma, cough, pharyngitis, upper respiratory tract infection

Postmarketing and/or case reports (Limited to important or life-threatening): Facial swelling


Concerns related to adverse effects:

• Adrenal suppression: May cause hypercorticism or suppression of hypothalamic-pituitary-adrenal (HPA) axis, particularly in younger children or in patients receiving high doses for prolonged periods. HPA axis suppression may lead to adrenal crisis.

• Contact dermatitis: Allergic contact dermatitis can occur, it is usually diagnosed by failure to heal rather than clinical exacerbation.

• Kaposi sarcoma: Prolonged treatment with corticosteroids has been associated with the development of Kaposi sarcoma (case reports); if noted, discontinuation of therapy should be considered (Goedert, 2002).

• Local effects: Local adverse reactions may occur (eg, skin atrophy, striae, telangiectasias, burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection miliaria); may be irreversible. Local adverse reactions are more likely to occur with occlusive and/or prolonged use. If irritation develops, discontinued use and institute appropriate therapy.

• Skin infections: Concomitant skin infections may be present or develop during therapy; discontinue if dermatological infection persists despite appropriate antimicrobial therapy.

• Systemic effects: Topical corticosteroids may be absorbed percutaneously. Absorption of topical corticosteroids may cause manifestations of Cushing syndrome, hyperglycemia, or glycosuria. Use of the foam for >4 weeks may suppress the immune system. Absorption of topical corticosteroids is increased by the use of occlusive dressings, application to denuded skin, or application to large surface areas.

Special populations:

• Pediatric: Chronic use of corticosteroids in children may interfere with growth and development.

Dosage forms specific issues:

• Foam: Flammable; keep away from fire or flame. Instruct patients to avoid smoking during and immediately after application.

Monitoring Parameters

HPA axis suppression (ACTH stimulation test, AM plasma cortisol test, urinary free cortisol test); signs of bacterial or fungal infection

Pregnancy Risk Factor


Pregnancy Considerations

Adverse events have been observed in animal reproduction studies.

Patient Education

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience dry skin, burning, or stinging. Have patient report immediately to prescriber signs of high blood sugar (confusion, feeling sleepy, more thirst, hunger, passing urine more often, flushing, fast breathing, or breath that smells like fruit), signs of skin changes (pimples, stretch marks, slow healing, or hair growth), severe skin irritation, or skin discoloration (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.