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Clobetasol Propionate

Pronunciation: kloe-BEE-tah-sahl PRO-pee-oh-nate
Class: Corticosteroid, Topical

Trade Names

- Lotion 0.05%
- Shampoo 0.05%

- Cream 0.05%
- Ointment 0.05%
- Scalp application 0.05%

- Foam 0.05%

- Foam 0.05%

- Cream 0.05%
- Gel 0.05%
- Ointment 0.05%
- Scalp application 0.05%

Temovate Emollient
- Cream 0.05%

Dermovate (Canada)
Gen-Clobetasol (Canada)
ratio-Clobetasol (Canada)
Taro-Clobetasol (Canada)


Topical glucocorticoid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Thought to act by inducing phospholipase A 2 inhibitory proteins, thus controlling biosynthesis of potent mediators of inflammation.

Indications and Usage

Relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses; moderate to severe plaque-type psoriasis ( Olux foam, Clobex lotion, Temovate E cream).


Primary scalp infections (scalp application formulation). Standard considerations.

Dosage and Administration

Adults and Children over 12 yr of age

Topical Apply thin film to affected area twice daily. When using the foam, apply directly to the affected area. Treatment (except psoriasis) should be limited to 2 consecutive wk and less than 50 g/wk or 50 mL/wk. In psoriasis, no more than 4 consecutive wk and less than 50 g/wk.

General Advice

  • For topical use only. Not for ophthalmic, oral, or intravaginal use.
  • Do not apply to face, groin, or axillae.
  • Apply cream, ointment, gel, lotion, or scalp application sparingly, but in sufficient quantity, to cover affected areas; rub in gently.
  • Apply scalp application to affected scalp areas twice daily, once in the morning and once at night. Do not use near open flame.
  • Apply foam to affected area(s) twice daily, once in the morning and once at night, gently massaging into affected area until foam disappears. Hold can upside down and depress applicator to squirt a small amount of foam into the cap of the can, a saucer, or other cool surface, or on the affected skin area. Do not squirt foam directly into hand (unless hand is affected area) because the foam will begin to melt right away on contact with warm skin.
  • Avoid contact with the eyes. If medication does come into contact with the eyes, wash the eye(s) with large amounts of cool water. Notify health care provider if eye irritation occurs.


Store cream and ointment at controlled room temperature (59° to 86°F). Do not refrigerate cream. Store gel in refrigerator (36° to 46°F) or at controlled room temperature. Store scalp application between 39° and 77°F. Do not use near open flame. Store lotion and foam at controlled room temperature (68° to 77°F). Avoid fire, flame, or smoking during and immediately following application of foam.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Burning; stinging; pruritus; irritation; erythema; folliculitis; cracking, fissuring, and numbness of fingers; elbow tenderness; skin atrophy; telangiectasia; hypertrichosis.



Category C .




Not recommended in children under 12 yr of age. Children are at higher risk than adults of HPA axis suppression and Cushing syndrome when they are treated with topical corticosteroids.


Not for use in treating rosacea or perioral dermatitis; should not be used on face, groin, or axillae.

Occlusive dressings

Do not use gel or scalp application with occlusive dressings.


Systemic absorption may produce HPA axis suppression and systemic side effects; HPA axis suppression shown at doses as low as 2 g/day.

Patient Information

  • Teach patient or caregiver proper technique for applying cream, ointment, lotion, gel, scalp application, or foam: wash hands; apply sufficient cream or ointment to cover affected areas sparingly and gently massage into skin; wash hands after applying cream or ointment.
  • Advise patient to apply medication twice daily as directed by health care provider.
  • Advise patient that if a dose is missed to apply it as soon as remembered and then continue on regular schedule. If it is almost time for the next application, instruct patient to skip the dose and continue on regular schedule. Caution patient not to apply double doses.
  • Caution patient not to apply to face, underarms, or groin area unless directed by health care provider.
  • Caution patient not to bandage, cover, or wrap treated skin areas or use cosmetics or other skin products over treated areas unless advised by health care provider.
  • Caution patient to avoid contact with the eyes. Advise patient that if medication does come into contact with the eyes, to wash eyes with large amounts of cool water and contact health care provider if eye irritation occurs.
  • Advise patient that symptoms should begin to improve fairly soon after starting treatment and to notify health care provider if condition does not improve, worsens, or if application site reactions (eg, burning, stinging, redness, itching) develop.
  • Advise patient that therapy is usually discontinued when control has been achieved.

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