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Vinorelbine

Generic Name: vinorelbine (vin OR el been)
Brand Name: Navelbine

Medically reviewed by Drugs.com on Nov 5, 2018 – Written by Cerner Multum

What is vinorelbine?

See also: Alunbrig

Vinorelbine is used to treat non-small cell lung cancer.

Vinorelbine is sometimes used in combination with other cancer medications.

Vinorelbine may also be used for other purposes not listed in this medication guide.

Important Information

Vinorelbine affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, tiredness, cough, skin sores, bruising, pale skin, unusual bleeding, or trouble breathing.

Before taking this medicine

You should be treated with vinorelbine if you are allergic to it, or if you have severely low white blood cell counts.

Tell your doctor if you have ever had:

Vinorelbine may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

Vinorelbine can damage sperm. A man taking vinorelbine should use a condom during treatment, and for at least 3 months after treatment ends.

You should not breast-feed while using vinorelbine.

How is vinorelbine given?

Vinorelbine is given as an infusion into a vein. A healthcare provider will give you this injection.

Vinorelbine is usually given once every 7 days to 6 weeks. Your schedule will depend on the condition being treated. Follow your doctor's dosing instructions very carefully.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when vinorelbine is injected.

Vinorelbine can lower your blood cell counts. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your vinorelbine injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include white patches or sores in your mouth or throat, painful swallowing, heartburn, severe constipation, and stomach pain.

What should I avoid while receiving vinorelbine?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Do not receive a "live" vaccine while using vinorelbine, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

vinorelbine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Vinorelbine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe constipation, stomach pain, bloody or black stools;

  • numbness, tingling, muscle weakness;

  • pain, redness, numbness, and peeling skin on your hands or feet;

  • new or worsening cough, wheezing, chest tightness, trouble breathing;

  • pain, burning, irritation, or skin changes where the injection was given; or

  • low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Vinorelbine can cause severe constipation. Talk with your doctor about ways to avoid constipation while you are being treated with vinorelbine.

Common side effects may include:

  • nausea, vomiting, constipation;

  • weakness;

  • numbness or tingling in your hands or feet;

  • low blood cell counts;

  • abnormal liver function tests; or

  • pain, redness, bruising, or irritation around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Vinorelbine dosing information

Usual Adult Dose for Non-Small Cell Lung Cancer:

vinorelbine 30 mg/m2 administered weekly as a single agent. The recommended method of administration is an intravenous injection over 6 to 10 minutes. In controlled trials, single-agent vinorelbine was given weekly until progression or dose-limiting toxicity.

or

vinorelbine 25 mg/m2 weekly in combination with cisplatin. Blood counts should be checked weekly to determine whether dose reductions of vinorelbine and/or cisplatin are necessary. (In the SWOG study, most patients required a 50% dose reduction of vinorelbine at day 15 of each cycle and a 50% dose reduction of cisplatin by cycle 3.)

or

vinorelbine 30 mg/m2 weekly in combination with cisplatin.

What other drugs will affect vinorelbine?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect vinorelbine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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