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Generic name: vinorelbine [ vin-OR-el-been ]
Brand name: Navelbine
Dosage form: intravenous solution (10 mg/mL)
Drug class: Mitotic inhibitors

Medically reviewed by on Apr 3, 2023. Written by Cerner Multum.

What is vinorelbine?

Vinorelbine is used to treat non-small cell lung cancer, sometimes used in combination with other cancer medications.

Vinorelbine may also be used for other purposes not listed in this medication guide.

Vinorelbine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Vinorelbine may cause serious side effects. Call your doctor at once if you have:

Talk with your doctor about ways to avoid severe constipation while you are being treated with vinorelbine.

Common side effects of vinorelbine may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, tiredness, cough, skin sores, bruising, pale skin, unusual bleeding, or trouble breathing.

Before taking this medicine

You should not be treated with vinorelbine if you are allergic to it, or if you have severely low white blood cell counts.

Tell your doctor if you have ever had:

Vinorelbine can harm an unborn baby or cause birth defects if the mother or the father is using vinorelbine.

Vinorelbine can damage sperm and it may be harder for you to get a woman pregnant while you are using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

You should not breastfeed while using vinorelbine, and for at least 9 days after your last dose.

How is vinorelbine given?

Vinorelbine is given as an infusion into a vein. A healthcare provider will give you this injection.

Vinorelbine is usually given once every 7 days to 6 weeks. Your schedule will depend on the condition being treated. Follow your doctor's dosing instructions very carefully.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when vinorelbine is injected.

Vinorelbine affects your immune system. You may get infections more easily, even serious or fatal infections. Your blood will need to be tested often and your treatment may be delayed based on the results.

Vinorelbine dosing information

Usual Adult Dose for Non-Small Cell Lung Cancer:

25 mg/m2 IV over 6 to 10 minutes on Days 1, 8, 15, and 21 of a 28-day cycle in combination with cisplatin 100 mg/m2 IV on Day 1 only of each 28-day cycle
30 mg/m2 IV over 6 to 10 minutes once a week in combination with cisplatin 120 mg/m2 IV on Days 1 and 29, then every 6 weeks

30 mg/m2 IV over 6 to 10 minutes once a week

-In combination with cisplatin for first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
-As a single agent, for the treatment of patients with metastatic NSCLC

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your vinorelbine injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include white patches or sores in your mouth or throat, painful swallowing, heartburn, severe constipation, and stomach pain.

What should I avoid while receiving vinorelbine?

Do not receive a "live" vaccine while using vinorelbine, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

What other drugs will affect vinorelbine?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect vinorelbine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.