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Generic Name: vinorelbine (vin OR el been)
Brand Name: Navelbine

Medically reviewed by on March 25, 2020. Written by Cerner Multum.

What is Navelbine?

Navelbine is used to treat non-small cell lung cancer.

Navelbine is sometimes used in combination with other cancer medications.

Navelbine may also be used for other purposes not listed in this medication guide.

Important Information

Navelbine affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, tiredness, cough, skin sores, bruising, pale skin, unusual bleeding, or trouble breathing.

Before taking this medicine

You should not be treated with Navelbine if you are allergic to it, or if you have severely low white blood cell counts.

Tell your doctor if you have ever had:

  • liver disease;

  • bone marrow suppression;

  • a nerve disorder; or

  • radiation therapy or other cancer treatments.

Navelbine can harm an unborn baby or cause birth defects if the mother or the father is using Navelbine.

  • If you are a woman, you may need to have a negative pregnancy test before starting this treatment. Do not use Navelbine if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Navelbine.

Navelbine can damage sperm and may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because this medicine can harm an unborn baby.

You should not breastfeed while using Navelbine, and for at least 9 days after your last dose.

How is Navelbine given?

Navelbine is given as an infusion into a vein. A healthcare provider will give you this injection.

Navelbine is usually given once every 7 days to 6 weeks. Your schedule will depend on the condition being treated. Follow your doctor's dosing instructions very carefully.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Navelbine is injected.

Navelbine can lower your blood cell counts. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Navelbine.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include white patches or sores in your mouth or throat, painful swallowing, heartburn, severe constipation, and stomach pain.

What should I avoid while receiving Navelbine?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Do not receive a "live" vaccine while using Navelbine, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

Navelbine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe constipation, stomach pain, bloody or black stools;

  • numbness, tingling, muscle weakness;

  • pain, redness, numbness, and peeling skin on your hands or feet;

  • new or worsening cough, wheezing, chest tightness, trouble breathing;

  • dark urine, jaundice (yellowing of the skin or eyes);

  • pain, burning, irritation, or skin changes where the injection was given; or

  • low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Navelbine can cause severe constipation. Talk with your doctor about ways to avoid constipation while you are being treated with this medicine.

Common side effects may include:

  • nausea, vomiting, constipation;

  • weakness;

  • numbness or tingling in your hands or feet;

  • low blood cell counts;

  • abnormal liver function tests; or

  • pain, redness, bruising, or irritation around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Navelbine?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect Navelbine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.