Generic Name: tolazamide (tole AZ a mide)
Brand Name: Tolinase
What is tolazamide?
Tolazamide is an oral diabetes medicine that helps control blood sugar levels. This medicine helps your body respond better to insulin produced by your pancreas.
Tolazamide is used together with diet and exercise to treat type 2 diabetes. Other diabetes medicines are sometimes used in combination with tolazamide if needed.
Tolazamide should not be used by itself to treat type 1 diabetes.
Tolazamide may also be used for purposes not listed in this medication guide.
What is the most important information I should know about tolazamide?
Do not use this medicine if you are in a state of diabetic ketoacidosis. Call your doctor for treatment with insulin.
What should I discuss with my healthcare provider before taking tolazamide?
You should not use this medicine if you are allergic to tolazamide, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
To make sure tolazamide is safe for you, tell your doctor if you have:
kidney disease; or
a history of heart disease.
Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of taking tolazamide.
It is not known whether tolazamide will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using tolazamide.
It is not known whether tolazamide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
How should I take tolazamide?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Tolazamide is usually taken once a day, with breakfast or the first main meal of the day. Follow your doctor's instructions.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.
Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, confusion, irritability, dizziness, or feeling shaky. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.
If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.
Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.
Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.
Use tolazamide regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Tolazamide is only part of a treatment program that may also include diet, exercise, weight control, regular blood sugar testing, and special medical care. Follow your doctor's instructions very closely.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember (be sure to take the medicine with food). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A tolazamide overdose can cause life-threatening hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
What should I avoid while taking tolazamide?
Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.
Tolazamide side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe skin rash, redness, or itching;
easy bruising or bleeding,
fever, chills, sore throat, mouth sores;
pale or yellowed skin, dark colored urine;
low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery; or
low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Tolazamide dosing information
Usual Adult Dose for Diabetes Type 2:
Initial dose: 100 to 250 mg orally once a day
-Adjust dose based on blood glucose response
Maintenance dose: Average 250 to 500 mg/day; range: 100 to 1000 mg per day
-For doses greater than 500 mg, the dose maybe divided and given twice a day
Maximum dose: 1000 mg per day
-For patients with a fasting blood glucose less than 200 mg/dL, the usual starting dose is 100 mg per day.
-Patients will generally have no further response to doses greater than 1000 mg/day
-Transferring patients from other antidiabetic regimens should be done conservatively: see dose adjustment section.
Use: As an adjunct to diet to lower blood glucose in patients with type 2 diabetes whose hyperglycemia cannot be controlled by diet alone.
Usual Geriatric Dose for Diabetes Type 2:
Initial dose: 100 mg orally once a day
What other drugs will affect tolazamide?
You may be more likely to have hypoglycemia (low blood sugar) if you take tolazamide with other drugs that can lower blood sugar, such as:
aspirin or other salicylates (including Pepto Bismol);
a blood thinner (warfarin, Coumadin, Jantoven);
sulfa drugs (Bactrim, SMZ-TMP, and others);
a monoamine oxidase inhibitor (MAOI); or
insulin or other oral diabetes medications.
This list is not complete, and many other medicines can increase or decrease the effects of tolazamide on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with tolazamide. Not all possible interactions are listed in this medication guide.
More about tolazamide
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- En Español
- 0 Reviews – Add your own review/rating
- Drug class: sulfonylureas
Other brands: Tolinase
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about tolazamide.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 3.12.
Date modified: May 03, 2017
Last reviewed: October 15, 2015