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Generic name: tezepelumab [ TEZ-e-PEL-ue-mab ]
Brand names: Tezspire Pre-filled Pen, Tezspire Pre-filled Syringe, Tezspire
Dosage form: subcutaneous solution (ekko 210 mg/1.91 mL)
Drug class: Selective immunosuppressants

Medically reviewed by on Aug 17, 2023. Written by Cerner Multum.

What is tezepelumab?

Tezepelumab is used together with other medicines for the maintenance treatment of severe asthma in people 12 years and older and whose asthma is not controlled with their current medication.

Tezepelumab is not a fast-acting rescue medicine for asthma attacks or bronchospasms. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working.

Tezepelumab may also be used for purposes not listed in this medication guide.

Tezepelumab side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during or after the injection. Tell your caregiver if you feel dizzy, nauseated, light-headed, itchy, short of breath, or if you have swelling in your face.

Common side effects of tezepelumab may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not be treated with tezepelumab if you are allergic to it.

Tell your doctor if you have ever had:

  • a severe allergic reaction;

  • a parasite (helminth) infection; or

  • if you are scheduled to receive or have received a live vaccine recently.

Tell your doctor if you are pregnant, plan to get pregnant, or if you are breastfeeding or plan to breastfeed.

How should I receive tezepelumab?

Tezepelumab is injected under the skin, usually once every 4 weeks. A healthcare provider will give you this injection.

You will be watched closely for a short time after each injection, to make sure you do not have an allergic reaction.

If you also use a steroid medication, you should not stop using it suddenly. Follow your doctor's instructions about tapering your dose.

Tezepelumab dosing information

Usual Adult Dose for Asthma:

210 mg subcutaneously every 4 weeks

-This drug is not indicated for the relief of acute bronchospasm or status asthmaticus.

Use: As add-on maintenance treatment for severe asthma.

Usual Pediatric Dose for Asthma:

12 years or older: 210 mg subcutaneously every 4 weeks

-This drug is not indicated for the relief of acute bronchospasm or status asthmaticus.

Use: As add-on maintenance treatment for severe asthma in pediatric patients 12 years or older.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your tezepelumab injection.

What happens if I overdose?

Since tezepelumab is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving tezepelumab?

Avoid receiving a "live" vaccine. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

What other drugs will affect tezepelumab?

Other drugs may affect tezepelumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Popular FAQ

Your healthcare provider can show you how to self-administer the Tezspire pen. Do not attempt to administer it yourself until you have received full instructions. Take it out of the refrigerator, and leave it in the carton and allow it to come to room temperature between 68°F to 77˚F (20°C to 25°C) for about 60 minutes before giving the injection. Do not remove the cap just yet. Continue reading

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.