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Maprotiline

Generic name: maprotiline [ ma-PROE-ti-leen ]
Brand name: Ludiomil
Dosage form: oral tablet (25 mg; 50 mg; 75 mg)
Drug class: Tetracyclic antidepressants

What is maprotiline?

Maprotiline is an antidepressant that is used to treat major depressive disorder, depressive neurosis, manic depressive illness, or anxiety related to depression.

Maprotiline may also be used for purposes not listed in this medication guide.

Warnings

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Before taking this medicine

You should not use maprotiline if you are allergic to it, or:

  • if you have a seizure disorder; or

  • if you recently had a heart attack.

Do not use maprotiline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Not approved for use by anyone younger than 18 years old.

Tell your doctor if you have ever had:

  • bipolar disorder (manic depression);

  • seizures;

  • glaucoma;

  • heart disease or a heart rhythm disorder;

  • a heart attack or stroke;

  • urination problems;

  • overactive thyroid; or

  • electroshock therapy.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

Older adults may be more sensitive to the effects of maprotiline.

How should I take maprotiline?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Your symptoms may not improve for up to 3 weeks.

Call your doctor if your symptoms do not improve, or if they get worse.

Tell your doctor if you have a planned surgery.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal.

Overdose may cause drowsiness, fast or irregular heartbeats, vomiting, blue lips or fingernails, fainting, dilated pupils, or seizure.

What should I avoid while taking maprotiline?

Avoid driving or hazardous activity until you know how maprotiline will affect you. Your reactions could be impaired.

Maprotiline side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • blurred vision, eye pain or redness, seeing halos around lights;

  • confusion, hallucinations;

  • unusual thoughts or behavior;

  • memory problems;

  • fever, sore throat; or

  • jaundice (yellowing of the skin or eyes).

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Maprotiline dosing information

Usual Adult Dose for Depression:

Outpatients with Mild to Moderate Depression:
-Initial dose: 75 mg orally once a day or in divided doses
-Maintenance dose: 75 to 150 mg/day
-Maximum dose: 225 mg/day

Inpatients with Moderate to Severe Depression:
-Initial dose: 100 to 150 mg orally once a day or in divided doses
-Maintenance dose: 75 to 150 mg/day
-Maximum dose: 225 mg/day

Comments:
-Patients with mild to moderate depression should remain on the initial dose for at least 2 weeks. Titration should gradually increase in 25 mg increments.
-Therapeutic efficacy may be reached by most outpatients at 150 mg/day; however, hospitalized and/or severely depressed patients may require doses up to 225 mg/day.

Uses:
-Treatment of depressive illness in patients with dysthymic disorder/depressive neurosis and major depressive disorder/manic depressive illness, depressed type
-Relief of anxiety related to depression

Usual Geriatric Dose for Depression:

Outpatients with Mild to Moderate Depression:
-Initial dose: 25 mg orally once a day or in divided doses
-Maintenance dose: 50 to 75 mg/day

Comment:
-Patients over the age of 60 years had a satisfactory response with a maintenance dose of 50 to 75 mg/day; this range should be considered for all patients, and especially in those who cannot tolerate higher doses.

Uses:
-Treatment of depressive illness in patients with dysthymic disorder/depressive neurosis and major depressive disorder/manic depressive illness, depressed type
-Relief of anxiety related to depression

What other drugs will affect maprotiline?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your other medicines, especially:

  • any other antidepressant;

  • antipsychotic medicine;

  • blood pressure medicine; or

  • thyroid medication.

This list is not complete and many other drugs may affect maprotiline. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.