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Hyoscyamine and phenyltoloxamine

Generic name: hyoscyamine and phenyltoloxamine [ HYE-oh-SYE-a-meen-and-FEEN-il-toe-LOX-a-meen ]
Brand name: Digex NF
Dosage form: oral capsule (0.0625 mg-15 mg)
Drug class: Anticholinergics / antispasmodics

Medically reviewed by on Sep 20, 2022. Written by Cerner Multum.

What is hyoscyamine and phenyltoloxamine?

Hyoscyamine and phenyltoloxamine is a combination medicine that is used to treat indigestion (upset stomach, gas, bloating), and to reduce stomach acid.

Hyoscyamine and phenyltoloxamine may also be used for purposes not listed in this medication guide.


You should not use hyoscyamine and phenyltoloxamine if you have severe ulcerative colitis, or if you are unable to urinate.

Before you take hyoscyamine and phenyltoloxamine, tell your doctor if you have glaucoma, asthma, heart disease, high blood pressure, coronary artery disease, or a thyroid disorder.

Before taking this medicine

You should not use this medicine if you are allergic to hyoscyamine or phenyltoloxamine, or if:

  • you have severe ulcerative colitis; or

  • you are unable to urinate.

You may not be able to take this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma, heart disease, high blood pressure, coronary artery disease, or a thyroid disorder.

Tell your doctor if you have or have had:

  • a bladder obstruction or other urination problems;

  • an enlarged prostate;

  • ulcerative colitis;

  • glaucoma;

  • myasthenia gravis;

  • liver or kidney disease;

  • heart problems; or

  • breathing problems.

Tell your doctor if you are pregnant or breastfeeding.

Do not give this medicine to a child without medical advice.

How should I take hyoscyamine and phenyltoloxamine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take with food.

If you break or open a hyoscyamine and phenyltoloxamine capsule, avoid inhaling the powder medicine inside the capsule.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take your dose as soon as you can, but only if you are getting ready to eat a meal. If you skip a meal, skip the missed dose and wait until your next meal.

Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking hyoscyamine and phenyltoloxamine?

Avoid taking hyoscyamine and phenyltoloxamine at the same time you take an antacid. Antacids can make it harder for your body to absorb hyoscyamine and phenyltoloxamine. You may take the antacid after you have taken hyoscyamine and phenyltoloxamine and eaten a meal.

Drinking alcohol with this medicine can cause side effects.

This medicine may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

Avoid becoming overheated or dehydrated during exercise and in hot weather. This medicine can decrease sweating and you may be more prone to heat stroke.

Hyoscyamine and phenyltoloxamine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Hyoscyamine and phenyltoloxamine may cause serious side effects. Stop using hyoscyamine and phenyltoloxamine and call your doctor at once if you have:

  • pounding heartbeats or fluttering in your chest;

  • severe stomach cramps or constipation;

  • little or no urination;

  • confusion, memory problems, slurred speech;

  • diarrhea; or

  • problems with balance or muscle movement.

Side effects such as dry mouth, constipation, and confusion may be more likely in older adults.

Common side effects of hyoscyamine and phenyltoloxamine may include:

  • dizziness, drowsiness;

  • constipation;

  • decreased sweating, decreased urination;

  • dry mouth;

  • blurred vision; or

  • impotence, loss of interest in sex, or trouble having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hyoscyamine and phenyltoloxamine?

Using hyoscyamine and phenyltoloxamine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect hyoscyamine and phenyltoloxamine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

More about hyoscyamine / phenyltoloxamine

Patient resources

Other brands

Digex NF

Related treatment guides

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.