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Generic name: menthol topicalMEN-thol-TOP-ik-al ]
Brand names: ActivICE, Aspercreme Heat Pain Relieving, Biofreeze, Blue Gel, Flexall, ... show all 11 brands
Drug class: Topical rubefacient

Medically reviewed by on Oct 13, 2023. Written by Cerner Multum.

What is Flexall?

Flexall (for use on the skin) is used to treat adults and children at least 2 years old to provide temporary relief of muscle or joint pain caused by strains, sprains, arthritis, bruising, or backaches.

Flexall powder is used to treat pain and itching caused by minor cuts, sunburn, insect bites, minor burns, scrapes, or other skin irritations.

There are many brands and forms of menthol available. Not all brands are listed on this leaflet.

Flexall may also be used for purposes not listed in this medication guide.

Flexall side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Flexall may cause serious side effects. Stop using Flexall and call your doctor at once if you have:

Less serious side effects may be more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Follow all directions on the label and package. Use exactly as directed.

Before taking this medicine

Ask a doctor or pharmacist if Flexall is safe to use if you have ever had an allergy or if you have sensitive skin.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Do not give this medicine to a child without medical advice.

How should I use Flexall?

Use exactly as directed on the label, or as prescribed by your doctor.

Do not take by mouth. Topical medicine is for use only on the skin. Do not use on open wounds, damaged skin, broken skin, or irritated skin.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using exactly as directed on the label, or as prescribed by your doctor.

Wash your hands before and after applying this medicine. Use a mild soap to clean the skin area to be treated.

Do not cover treated skin with a bandage or use a heating pad unless your doctor tells you to.

Menthol can cause a cold or burning sensation, which is usually mild and should lessen over time with continued use. If this sensation causes significant discomfort, wash the skin with soap and water.

Stop using this medicine and call your doctor if your symptoms do not improve after 7 days, or if your symptoms get better and then come back in a few days.

Store tightly closed at cool room temperature away from moisture and heat. Protect from direct sunlight and keep away from open flame or high heat.

What happens if I miss a dose?

Flexall is used when needed. If you are on a dosing schedule, skip any missed dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medicine.

What should I avoid while using Flexall?

Avoid getting Flexall in your eyes, nose, or mouth. Rinse with water if this medicine gets in your eyes, nose, or mouth.

Avoid using other medications on the areas you treat with Flexall, unless you doctor tells you to.

What other drugs will affect Flexall?

Medicine used on the skin is not likely to be affected by other drugs you use, but many drugs can interact. Tell your doctor about all your current medicines, including prescription and over-the-counter medicines, vitamins, and herbal products.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.