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Campath

Generic name: alemtuzumab (AL em TOOZ ue mab)
Brand name: Campath
Drug class: CD52 monoclonal antibodies

Medically reviewed by Drugs.com on Mar 2, 2021. Written by Cerner Multum.

What is Campath?

Campath is used to treat B-cell chronic lymphocytic leukemia in adults.

Lemtrada is used to treat relapsing forms of multiple sclerosis in adults (including active secondary progressive disease), after at least two other medicines did not work or have stopped working.

Lemtrada will not cure MS, but it can make relapses occur less often. Lemtrada is not for use in treating clinically isolated syndrome.

Campath may also be used for purposes not listed in this medication guide.

Warnings

Campath can cause life-threatening side effects, including serious medical problems that may occur months to years after you receive Campath.

Call your doctor right away if you have unusual bleeding or bruising, swelling in your legs or feet, decreased urination, blood in your urine or stools, coughing up blood, a lump or swelling in your neck, a hoarse voice, trouble swallowing or breathing, sudden weakness on one side of your body, or problems with vision, speech, or balance.

Before taking this medicine

You may not be able to use Campath if you are allergic to it, or if you have:

  • an active infection; or

  • HIV (human immunodeficiency virus).

Tell your doctor if you have ever had:

  • tuberculosis or other infections;

  • a thyroid disorder;

  • kidney disease;

  • bleeding problems, or if you receive blood transfusions; or

  • if you have received any vaccine in the past 6 weeks.

Tell your doctor if you have never had chickenpox or if you have never received a varicella vaccine (Varivax). You may need to receive the vaccine and then wait 6 weeks before using Lemtrada.

Lemtrada may increase your risk of developing other types of cancer, such as melanoma, thyroid cancer, lymphoma, or leukemia. Ask your doctor about this risk.

You may need to have a negative pregnancy test before starting this treatment. Campath may harm an unborn baby. Use effective birth control to prevent pregnancy while receiving this medicine, and for at least 3 months after your last dose of Campath and for 4 months after your last dose of Lemtrada. Tell your doctor if you become pregnant.

If you use Campath while you are pregnant, make sure any doctor caring for your new baby knows that you used the medicine during pregnancy. Being exposed to Campath in the womb could affect your baby's vaccination schedule.

Campath may affect fertility (ability to have children) in both men and women. However, women should still use birth control to prevent pregnancy because this medicine can harm an unborn baby.

It may not be safe to breastfeed while using Campath. You should not breastfeed while using Campath, and for at least 3 months after your last dose.

How is Campath given?

Campath is given as an infusion into a vein. A healthcare provider will give you this injection.

Campath is usually given 3 times per week for 12 weeks. Lemtrada is usually given in 2 or more treatment courses, separated by 1 year. Your doctor will determine how long to treat you and the number of courses you need.

Campath must be given slowly. The Campath infusion can take 2 hours to complete. The Lemtrada infusion can take 4 hours to complete.

You will be watched closely for up to 2 hours or longer after the infusion, to make sure you do not have a serious reaction.

You may be given other medicines to help prevent certain side effects or infections. Take these medicines for the full prescribed length of time.

Campath affects your immune system. You may get infections more easily, even serious or fatal infections. You will need frequent medical tests, and your next dose may be delayed based on the results.

Campath can have long lasting effects on your body. You may need medical tests for up to 2 months after you stop using Campath, or 4 years after you stop using Lemtrada.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Campath.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose may cause a severe reaction when the medicine is injected.

What should I avoid while receiving Campath?

Do not receive a "live" vaccine while using Campath. The vaccine may not work as well or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

While being treated with Lemtrada, avoid foods that may be a source of Listeria infection, or heat them thoroughly before consuming. This includes deli meat, undercooked meat, seafood, poultry, unpasteurized dairy products, or soft cheeses.

Campath side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during or shortly after the injection. Tell your caregiver if you feel weak, feverish, chilled, dizzy, nauseated, light-headed, or have a rash, wheezing, chest pain, trouble breathing, swelling in your mouth or throat, or fast, slow, or irregular heartbeats.

Campath can cause your immune system to attack cells and organs in your body. This can lead to serious medical problems that may occur months to years after you receive Campath or Lemtrada. Call your doctor at once if you have:

  • unusual bleeding or bruising, nosebleeds, bleeding gums, heavy menstrual periods, blood in your urine or stools, coughing up blood;

  • problems with speech, thought, vision, or muscle movement;

  • a mole that has changed in size or color;

  • cough, wheezing, chest pain, feeling short of breath, coughing up blood;

  • an overactive immune system--fever, swollen glands, rash, feeling unsteady or less alert, trouble waking, seizure;

  • liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes); or

  • kidney problems--swelling in your lower legs, weight gain, loss of appetite, sudden pain in your stomach and back, urine that looks pink/brown or foamy;

  • signs of infection--fever, chills, sore throat, cough, mouth sores, skin sores or blisters, tingling, burning pain, pale or yellowed skin, pain or burning when you urinate, dark urine, feeling light-headed, cold hands and feet;

  • signs of tuberculosis--cough, night sweats, loss of appetite, weight loss, and feeling very tired;

  • signs of a stroke or tear in an artery--sudden severe headache, weakness on one side of your body, drooping in your face, slurred speech;

  • gallbladder problems--fever, nausea, vomiting, and stomach pain;

  • thyroid problems--sweating, feeling cold, fast heartbeats, feeling nervous or tired, eye swelling, weight gain or loss; or

  • symptoms of thyroid cancer--a lump or swelling in your neck or throat, trouble swallowing, hoarse voice, or a new cough (not caused by a cold).

Common side effects may include:

  • reactions to the injection;

  • stomach pain, nausea, vomiting, diarrhea;

  • infections (fever, chills, runny or stuffy nose, mouth or throat pain, painful urination);

  • chest pain or tightness, coughing up blood;

  • rash, itching, tingling, hives;

  • dizziness, tiredness, trouble sleeping;

  • headache, joint pain, back pain, pain in your arms or legs;

  • thyroid problems; or

  • flushing (sudden warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Campath?

Tell your doctor about all your other medicines, especially drugs that weaken the immune system such as cancer medicine, or medicines to prevent organ transplant rejection.

Other drugs may affect Campath, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Does Campath interact with my other drugs?

Enter other medications to view a detailed report.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.