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Cabometyx

Generic Name: cabozantinib (KA boe ZAN ti nib)
Brand Name: Cabometyx, Cometriq

Medically reviewed on Jan 26, 2018

What is Cabometyx?

Cabometyx interferes with the growth of some cancer cells.

Cabometyx is used to treat advanced kidney cancer, or thyroid cancer that has spread to other parts of the body.

Cabometyx may also be used for purposes not listed in this medication guide.

Important Information

Cabometyx may cause a perforation (a hole or tear) or a fistula (an abnormal passageway) within your stomach or intestines. This medicine can also increase your risk of serious bleeding.

Call your doctor if you have: severe stomach pain, choking or gagging when you eat or drink, unusual bleeding, bloody or tarry stools, heavy menstrual bleeding, or if you cough up blood.

Before taking this medicine

You should not use Cabometyx if you are allergic to it.

Tell your doctor if you have:

Cabometyx may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using Cabometyx and for at least 4 months after your last dose.

You should not breast-feed while using this medicine, and for at least 4 months after your last dose.

How should I take Cabometyx?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not use Cabometyx tablets in place of cabozantinib capsules. Take only the pill form your doctor has prescribed. Avoid medication errors by always checking the medicine you receive at the pharmacy.

Take Cabometyx on an empty stomach, at least 1 hour before or 2 hours after you eat anything.

Take this medicine with a full glass of water.

Do not crush, chew, or break a tablet, and do not open a capsule. Swallow the pill whole.

Your blood pressure will need to be checked often.

If you need surgery or dental work, stop taking Cabometyx at least 28 days ahead of time.

If you have stopped taking Cabometyx for any reason, talk with your doctor before you start taking it again.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Cabometyx?

Grapefruit may interact with Cabometyx and lead to unwanted side effects. Avoid the use of grapefruit products while taking this medicine.

Cabometyx can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Cabometyx side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Cabometyx may cause a perforation (a hole or tear) or a fistula (an abnormal passageway) within your stomach or intestines. Call your doctor if you have severe stomach pain, or if you feel like you are choking and gagging when you eat or drink.

Call your doctor at once if you have:

  • severe or ongoing vomiting or diarrhea;

  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • heavy menstrual bleeding, or any other bleeding that will not stop;

  • pain, tenderness, redness, swelling, blistering, or peeling skin on the palms of your hands or the soles of your feet;

  • a light-headed feeling, like you might pass out;

  • confusion, change in mental status, seizure (convulsions);

  • increased blood pressure--severe headache, blurred vision, pounding in your neck or ears;

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, sweating;

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; or

  • signs of a blood clot--chest pain, cough, trouble breathing, swelling or warmth in your arms or legs.

Your future doses of cabozantinib may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Cabometyx?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may interact with cabozantinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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