Generic Name: bupivacaine liposome (bue PIV a kane LYE poe some)
Brand Name: Exparel
What is bupivacaine liposome?
Bupivacaine is an anesthetic (numbing medicine) that blocks nerve impulses in your body.
Bupivacaine liposome is used as a local (in only one area) anesthetic to numb an area of your body for a minor surgery such as bunion removal or hemorrhoid surgery.
Bupivacaine may also be used for purposes not listed in this medication guide.
What is the most important information I should know about bupivacaine liposome?
Call your doctor if you have numbness, weakness, joint pain or stiffness, loss of movement, or if you still feel numb several hours after your surgery.
What should I discuss with my healthcare provider before receiving bupivacaine liposome?
Tell your doctor if you have ever had an allergic reaction to any type of numbing medicine.
To make sure bupivacaine liposome is safe for you, tell your doctor if you have:
a heart rhythm disorder; or
a history of seizures.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.
Bupivacaine liposome can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How is bupivacaine liposome given?
Bupivacaine is given as an injection placed into an area near your surgical incision. You will receive this injection in a hospital or surgical setting.
Some numbing medications can have long-lasting or delayed effects. Talk to your doctor if you have concerns about this risk. Call your doctor if you have joint pain or stiffness, or weakness in any part of your body that occurs after your surgery, even months later.
What happens if I miss a dose?
Since bupivacaine liposome is used as a single dose, it does not have a daily dosing schedule.
What happens if I overdose?
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid after receiving bupivacaine liposome?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Bupivacaine liposome side effects
Get emergency medical help if you have signs of an allergic reaction: hives, red rash, itching; sneezing, difficulty breathing; severe dizziness, vomiting; swelling of your face, lips, tongue, or throat.
You will be watched closely after receiving bupivacaine liposome, to make sure you do not have a reaction to the medicine. Tell your caregivers at once if you have any of these signs of a serious side effect:
ringing in your ears;
feeling restless or anxious;
feeling like you might pass out;
speech or vision problems, a metallic taste in your mouth;
numbness or tingling around your mouth;
tremors, twitching, mood changes;
fast heart rate, feeling short of breath, feeling unusually hot or cold;
numbness, weakness, or loss of movement where the injection was given; or
if you still feel numb several hours after your surgery.
Common side effects include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Bupivacaine liposome dosing information
Usual Adult Dose for Pain:
The manufacturer product information should be consulted.
Maximum dose: 266 mg once
-Bunionectomy dosing example: 106 mg (8 mL) administered as 7 mL infiltrated into the tissues surrounding the osteotomy and 1 mL into the subcutaneous tissue.
-Hemorrhoidectomy dosing example: 266 mg (20 mL) diluted with 10 mL of saline (30 mL total) and injected by visualizing the anal sphincter as a clock face and slowly infiltrating one 5 mL aliquot into each of the even numbers.
Use: Administration into the surgical site to produce postsurgical analgesia.
What other drugs will affect bupivacaine liposome?
It is not likely that other drugs you take orally or inject will interact with a single injection of bupivacaine liposome for local anesthesia. But many drugs can interact with each other. Tell your doctor about all your current medicines and any you start or stop using. This includes prescription, over-the-counter, vitamin, and herbal products.
Where can I get more information?
- Your doctor or pharmacist can provide more information about bupivacaine liposome.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 2.01.
Date modified: October 14, 2016
Last reviewed: February 02, 2015