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Amoxicillin, clarithromycin, and vonoprazan

Generic name: amoxicillin, clarithromycin, and vonoprazan [ a-MOX-i-SIL-in, kla-RITH-roe-MYE-sin, von-OH-pra-zan ]
Brand name: Voquezna Triple Pak
Dosage form: oral kit (500 mg-500 mg-20 mg)
Drug class: H. pylori eradication agents

Medically reviewed by on Nov 16, 2022. Written by Cerner Multum.

What is amoxicillin, clarithromycin, and vonoprazan (Voquezna Triple Pak)?

Amoxicillin, clarithromycin, and vonoprazan (Voquezna Triple Pak) is a combination medicine used to prevent stomach ulcer in adults caused by infection with Helicobacter pylori (H. pylori).

Amoxicillin, clarithromycin, and vonoprazan may also be used for purposes not listed in this medication guide.

Voquezna Triple Pak side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Amoxicillin, clarithromycin, and vonoprazan may cause serious side effects. Call your doctor at once if you have:

Older adults may be more sensitive to the effects of this medication.

Common side effects of amoxicillin, clarithromycin, and vonoprazan may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Tell your doctor about all your other medicines. Some drugs should not be used with amoxicillin, clarithromycin, and vonoprazan.

Before taking this medicine

You should not use amoxicillin, clarithromycin, and vonoprazan if you are allergic to amoxicillin, clarithromycin or vonoprazan, or similar medicines such as:

You should not use amoxicillin, clarithromycin, and vonoprazan if you have a history of cholestatic jaundice or liver problems with previous use of clarithromycin.

Some drugs should not be used with amoxicillin, clarithromycin, and vonoprazan. Your treatment plan may change if you also use:

Tell your doctor if you have ever had:

Amoxicillin, clarithromycin, and vonoprazan may harm an unborn baby. Tell your doctor if you are pregnant or plan to get pregnant.

It may be harder for you to get a woman pregnant while you are using this medicine.

Do not breastfeed while using this medicine. If you use a breast pump during this time, throw out the milk and do not feed it to your baby for at least 2 days after your last dose.

How should I take Voquezna Triple Pak?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take one vonoprazan tablet, two amoxicillin capsules, and one clarithromycin tablet twice daily (12 hours apart, in the morning and evening), with or without food for 14 days, unless your doctor tells you otherwise.

Keep using this medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication. Amoxicillin, clarithromycin, and vonoprazan will not treat a viral infection (flu or a common cold).

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using amoxicillin, clarithromycin, and vonoprazan.

Antibiotic medicines can cause diarrhea. Tell your doctor if you have diarrhea that is watery or bloody.

Store at room temperature away from moisture, heat, and light.

Amoxicillin, clarithromycin, and vonoprazan dosing information

Usual Adult Dose for Helicobacter pylori Infection:

Amoxicillin: 1000 mg orally twice a day
Clarithromycin: 500 mg orally twice a day
Vonoprazan: 20 mg orally twice a day

Duration of therapy: 14 days

Use: For the treatment of Helicobacter pylori infection

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if you are more than 4 hours late for the dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Voquezna Triple Pak?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Voquezna Triple Pak?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Amoxicillin, clarithromycin, and vonoprazan can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Tell your doctor about all your other medicines, especially:

This list is not complete and many other drugs may affect amoxicillin, clarithromycin, and vonoprazan. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.