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Amoxicillin and clavulanate potassium

Generic name: amoxicillin and clavulanate potassium [ am-OK-i-SIL-in-KLAV-ue-LAN-ate-poe-TAS-ee-um ]
Brand names: Augmentin, Augmentin ES-600, Augmentin XR
Dosage forms: oral powder for reconstitution (125 mg-31.25 mg/5 mL; 200 mg-28.5 mg/5 mL; 250 mg-62.5 mg/5 mL; 400 mg-57 mg/5 mL; 600 mg-42.9 mg/5 mL); oral tablet (250 mg-125 mg; 500 mg-125 mg; 875 mg-125 mg); oral tablet, chewable (200 mg-28.5 mg; 400 mg-57 mg); oral tablet, extended release (1000 mg-62.5 mg)
Drug class: Beta-lactamase inhibitors

Medically reviewed by on Feb 14, 2022. Written by Cerner Multum.

What is amoxicillin and clavulanate potassium?

Amoxicillin is a penicillin antibiotic. Clavulanate potassium helps prevent certain bacteria from becoming resistant to amoxicillin.

Amoxicillin and clavulanate potassium is a combination medicine used to treat many different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin.

Amoxicillin and clavulanate potassium may also be used for purposes not listed in this medication guide.


You should not use amoxicillin and clavulanate potassium if you have severe kidney disease, if you have had liver problems or jaundice while taking amoxicillin and clavulanate potassium, or if you are allergic to any penicillin or cephalosporin antibiotic, such as Amoxil, Ceftin, Cefzil, Moxatag, Omnicef, and others.

Before taking this medicine

You should not use this medicine if you are allergic to it, or if:

  • you have severe kidney disease (or if you are on dialysis);

  • you have had liver problems or jaundice while taking amoxicillin and clavulanate potassium; or

  • you are allergic to any penicillin or cephalosporin antibiotic, such as Amoxil, Ceftin, Cefzil, Moxatag, Omnicef, and others.

Tell your doctor if you have ever had:

The liquid or chewable tablet may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

Tell your doctor if you are pregnant or breastfeeding.

Amoxicillin and clavulanate potassium can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm, cervical cap, or contraceptive sponge) to prevent pregnancy.

Do not give this medicine to a child without medical advice.

How should I take amoxicillin and clavulanate potassium?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Amoxicillin and clavulanate potassium may work best if you take it at the start of a meal.

Take the medicine every 12 hours.

Do not crush or chew the extended-release tablet. Swallow the pill whole, or break the pill in half and take both halves one at a time. Tell your doctor if you have trouble swallowing a whole or half pill.

You must chew the chewable tablet before you swallow it.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

amoxicillin and clavulanate potassium can affect the results of certain medical tests. Tell any doctor who treats you that you are using amoxicillin and clavulanate potassium.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Amoxicillin and clavulanate potassium will not treat a viral infection such as the flu or a common cold.

Store the tablets at room temperature away from moisture and heat.

Store the liquid in the refrigerator. Throw away any unused liquid after 10 days.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause nausea, vomiting, stomach pain, diarrhea, skin rash, drowsiness, hyperactivity, and decreased urination.

What should I avoid while taking amoxicillin and clavulanate potassium?

Avoid taking amoxicillin and clavulanate potassium together with or just after eating a high-fat meal. This will make it harder for your body to absorb the medication.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Amoxicillin and clavulanate potassium side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Amoxicillin and clavulanate potassium may cause serious side effects. Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);

  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;

  • loss of appetite, upper stomach pain;

  • little or no urination; or

  • easy bruising or bleeding.

Common side effects of amoxicillin and clavulanate potassium may include:

  • nausea, vomiting; diarrhea;

  • rash, itching;

  • vaginal itching or discharge; or

  • diaper rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect amoxicillin and clavulanate potassium?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect amoxicillin and clavulanate potassium, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Frequently asked questions

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.