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Aldesleukin

Generic name: aldesleukin [ AL-des-LOO-kin ]
Brand name: Proleukin
Dosage form: intravenous powder for injection (22000000 intl units)
Drug classes: Interleukins, Miscellaneous antineoplastics

Medically reviewed by Drugs.com on Feb 16, 2024. Written by Cerner Multum.

What is aldesleukin?

Aldesleukin is used to treat kidney cancer or skin cancer than has spread to other parts of the body.

Aldesleukin may also be used for purposes not listed in this medication guide.

Aldesleukin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor right away if you have signs of a serious side effect called capillary leak syndrome: stuffy or runny nose followed by tiredness or dizziness, thirst, decreased urination, trouble breathing, and sudden swelling or weight gain.

Aldesleukin may cause serious side effects. Call your doctor at once if you have:

Common side effects of aldesleukin may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not be treated with aldesleukin if you have recently had abnormal lung or heart function tests.

Tell your doctor right away if you have signs of a serious side effect called capillary leak syndrome: stuffy or runny nose followed by tiredness or dizziness, thirst, decreased urination, trouble breathing, and sudden swelling or weight gain.

Also tell your doctor if you feel very drowsy during treatment.

Before taking this medicine

You should not be treated with aldesleukin if you are allergic to aldesleukin or interleukin-2, or if:

You may not be able to receive aldesleukin if you've had any of these side effects while receiving aldesleukin in the past:

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

How is aldesleukin given?

Aldesleukin is given as an infusion into a vein. A healthcare provider will give you this injection.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely.

You will need daily blood tests, and you may also need chest x-rays.

After 4 weeks off aldesleukin, your doctor will determine if you need to be treated again.

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, tell the doctor ahead of time if you have recently received aldesleukin. Some people treated with aldesleukin have had unusual allergic reactions to contrast agents used within weeks to several months later.

Aldesleukin dosing information

Usual Adult Dose for Renal Cell Carcinoma:

0.037 mg/kg (600,000 IU/kg) every 8 hours via a 15-minute IV infusion for a maximum of 14 doses; the schedule is repeated for another 14 doses after 9 days of rest.

Maximum Dose: 28 doses per course, as tolerated

Therapy Duration: During the first therapy course, metastatic RCC patients received a median of 20 doses and metastatic melanoma patients received a median of 18 doses.

Comments:
-Each treatment course consists of two 5-day treatment cycles separated by a rest period.
-Patient selection should include assessment of ECOG PS (Eastern Cooperative Oncology Group performance status).

Uses:
-Metastatic melanoma
-Metastatic renal cell carcinoma (metastatic RCC)

Usual Adult Dose for Melanoma -- Metastatic:

0.037 mg/kg (600,000 IU/kg) every 8 hours via a 15-minute IV infusion for a maximum of 14 doses; the schedule is repeated for another 14 doses after 9 days of rest.

Maximum Dose: 28 doses per course, as tolerated

Therapy Duration: During the first therapy course, metastatic RCC patients received a median of 20 doses and metastatic melanoma patients received a median of 18 doses.

Comments:
-Each treatment course consists of two 5-day treatment cycles separated by a rest period.
-Patient selection should include assessment of ECOG PS (Eastern Cooperative Oncology Group performance status).

Uses:
-Metastatic melanoma
-Metastatic renal cell carcinoma (metastatic RCC)

Opdivo, Keytruda, pembrolizumab, Avastin, nivolumab, bevacizumab, atezolizumab, Tecentriq, Mekinist, ipilimumab

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your aldesleukin injection.

What happens if I overdose?

Since aldesleukin is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving aldesleukin?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect aldesleukin?

Aldesleukin can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve).

Using aldesleukin with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Many drugs can affect aldesleukin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Does aldesleukin interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Aldesleukin Biosimilars

Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There is 1 for aldesleukin.

Proleukin (aldesleukin) - Iovance Biotherapeutics Manufacturing LLC
Formulation type Strength
Single-Dose Vial 22 MILLION INTERNATIONAL units (1.3 mg)

View Proleukin information in detail.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.