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Akynzeo for (injection)

Generic name: fosnetupitant and palonosetron (injection) [ FOS-net-UE-pi-tant-and-PAL-oh-NOE-se-tron ]
Brand name: Akynzeo for Injection
Drug class: Miscellaneous antiemetics

Medically reviewed by on Oct 12, 2022. Written by Cerner Multum.

What is Akynzeo for?

Akynzeo for is a combination medicine used to help prevent nausea and vomiting caused by chemotherapy. Akynzeo for is given together with a steroid called dexamethasone.

Akynzeo for helps prevent nausea and vomiting that occurs both during chemotherapy and later on (delayed nausea and vomiting).

Akynzeo for may also be used for purposes not listed in this medication guide.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

Akynzeo for may harm an unborn baby. Tell your doctor if you become pregnant.

Tell your doctor if you have ever had:

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, or serious infections. These medicines may interact with Akynzeo for and cause a serious condition called serotonin syndrome.

You should not breast-feed while using Akynzeo for.

Akynzeo for is not approved for use by anyone younger than 18 years old.

How is Akynzeo for given?

This medicine is given ahead of time and will not treat nausea or vomiting you already have.

About 30 minutes before chemotherapy, a healthcare provider will give you Akynzeo for as an infusion into a vein.

You will also take dexamethasone 30 minutes before chemotherapy, and you may need to keep taking dexamethasone for 3 days afterward. Follow your doctor's dosing instructions very carefully.

What happens if I miss a dose?

Akynzeo for is used as a single injection and does not have a daily dosing schedule.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving Akynzeo for?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Akynzeo for side effects

Get emergency medical help if you have signs of an allergic reaction: hives; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects of Akynzeo for may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Akynzeo for?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect Akynzeo for. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.