What types of hepatitis C (HCV) does Vosevi treat?

Some of the main differences between hepatitis B and C are:

• Hepatitis B virus can be prevented with a vaccine, but not hepatitis C.
• Hepatitis B and C are different viruses, but you can have both hepatitis B and hepatitis C at the same time.
• Over 90% of people infected with hepatitis C who have not received treatment can be cured with 8 to 12 weeks of oral medications, but treatment for hepatitis B, if needed, may be long-term or lifelong.
• There is no cure for hepatitis B, but once you recover from acute hepatitis B, you develop antibodies that protect you from the virus for life.

The newest drugs for the treatment of hepatitis C include Mavyret (glecaprevir and pibrentasvir), Vosevi (sofosbuvir, velpatasvir, and voxilaprevir), and Epclusa (sofosbuvir and velpatasvir). All are FDA-approved for the treatment of chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5 or 6 infection without cirrhosis or with compensated cirrhosis (Child-Pugh A), as well as other uses. In June 2025, Mavyret was approved for the treatment of acute HCV.

The cost of Mavyret for 84 tablets is $14,101 if you are paying cash using the Drugs.com online discount card, however, most people do not pay this amount. If you have commercial insurance, AbbVie offers a $5 per month Copay Savings Card for eligible patients.