What type of drug is Talzenna?
Talzenna (talazoparib) is a poly (ADP-ribose) polymerase (PARP) inhibitor that blocks PARP, a protein that is involved with cancer cell growth, regulation and repair. PARP inhibitors stop the cancer cells from being repaired which leads to cell death and a reduction in tumor growth.
PARP inhibitors are used to treat cancers that have mistakes in their DNA repair genes, such as with the BRCA gene mutation. PARP inhibitors are used to treat cancers such as: ovarian cancer, fallopian tube cancer, pancreatic cancer, peritoneal cancer, breast cancer and prostate cancer.
Talzenna is a prescription medicine approved:
1. As a single agent, for the treatment of adult patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm) HER2-negative locally advanced or metastatic breast cancer.
- This cancer has low or no amounts of HER2 protein, an abnormal inherited gene called BRCA and has spread to other parts of the body (locally advanced or metastatic). Your doctor will determine if you can use this treatment based on an FDA-approved diagnostic test.
2. In combination with enzalutamide (Xtandi) for the treatment of adult patients with HRR gene-mutated metastatic castration-resistant prostate cancer (mCRPC). Patients should also receive a gonadotropic-releasing hormone (GnRH) analog concurrently or should have had bilateral orchiectomy
- Castration-resistant prostate cancer no longer responds to a hormone therapy or surgical treatment to lower testosterone and metastatic means it has spread to other parts of the body.
Talzenna is given as a once-daily oral treatment and can be taken with or without food. Treatment is usually continued until disease progression or unacceptable toxicity.
Other PARP inhibitors include:
This is not all the information you need to know about Talzenna (talazoparib) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.
For a complete list of side effects, please refer to the individual drug monographs.
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References
- Talzenna (talazoparib) prescribing information. Pfizer, New York, NY. Updated June 2025. Accessed July 29, 2025 at https://labeling.pfizer.com/ShowLabeling.aspx?id=20582
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