Talazoparib

Generic name: talazoparib [ TAL-a-ZOE-pa-rib ]
Brand names: Talzenna, Talzenna Liquid-Filled
Dosage form: oral capsule (0.1 mg; 0.25 mg; 0.35 mg; 0.5 mg; 0.75 mg; 1 mg)
Drug class: PARP inhibitors

Medically reviewed by Drugs.com on Oct 17, 2023. Written by Cerner Multum.

What is talazoparib?

Talazoparib is used in adults to treat certain type of breast cancer that has spread to other parts of the body.

Talazoparib is also used in adults in combination with other drugs to treat prostate cancer that has spread to other parts of the body and when surgery or other treatments to decrease testosterone levels have not worked.

Your doctor will make sure you have the correct tumor type to be treated with talazoparib.

Talazoparib may also be used for purposes not listed in this medication guide.

Talazoparib side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Talazoparib may cause serious side effects. Call your doctor at once if you have:

• blood in your urine or stools;

• easy bruising, unusual bleeding, purple or red spots under your skin;

• weight loss;

• frequent infections;

• low red blood cells (anemia)--pale skin, weakness, tiredness, feeling light-headed or short of breath, cold hands and feet; or

• low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of talazoparib may include:

• low blood cell counts;

• an electrolyte imbalance (such as low blood levels of potassium or magnesium);

• bone injuries, low levels of calcium in your blood (hypocalcemia);

• high levels of bilirubin in the blood;

• high blood sugar;

• changes in your sense of taste

• nausea, vomiting, diarrhea, loss of appetite;

• hair loss;

• dizziness, headache; or

• feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Warnings

Using talazoparib may increase your risk of developing bone marrow problems or leukemia.

Talazoparib can lower your blood cell counts, and you may get infections or bleed more easily. Call your doctor if you have unusual bruising or bleeding, blood in your urine or stools, weight loss, fever, weakness, tiredness, or trouble breathing.

Your blood will be tested before and during treatment and your cancer treatments may be delayed based on the results.

Before taking this medicine

Tell your doctor if you have or have ever had:

• kidney disease.

Using talazoparib may increase your risk of developing bone marrow problems or leukemia. Ask your doctor about your individual risk.

Talazoparib can harm an unborn baby if the mother or the father is using talazoparib.

• If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 7 months after your last dose.

• If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.

• Tell your doctor right away if a pregnancy occurs.

It may be harder for you to get a woman pregnant while you are using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

How should I take talazoparib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take talazoparib with or without food.

Swallow the capsule whole and do not open or dissolve it.

If you vomit shortly after taking talazoparib, do not take another dose. Take your next dose as scheduled.

Talazoparib is usually given until your body no longer responds to the medication.

You may get infections or bleed more easily. Your blood will be tested before and during treatment and your cancer treatments may be delayed based on the results.

Store at room temperature away from moisture and heat.

Do not change your dose or stop using this medicine without your doctor's advice.

Talazoparib dosing information

Usual Adult Dose for Breast Cancer:

1 mg orally once a day until disease progression or unacceptable toxicity

Comments:
-Select patients based on the presence of germline BRCA mutations as determined by an FDA-approved test.

Use: For the treatment of adult patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm) HER2-negative locally advanced or metastatic breast cancer

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking talazoparib?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect talazoparib?

Tell your doctor about all your other medicines, especially:

• amiodarone;

• carvedilol;

• clarithromycin;

• itraconazole; or

• verapamil.

This list is not complete. Other drugs may affect talazoparib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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