Talazoparib Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 19, 2024.

Applies to talazoparib: oral capsule.

Serious side effects of talazoparib

Along with its needed effects, talazoparib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking talazoparib:

More common side effects

• black, tarry stools
• bleeding gums
• blood in the urine or stools
• bone pain or fracture
• chest pain
• chills
• cough
• fever
• hoarseness
• lower back or side pain
• painful or difficult urination
• pale skin
• pinpoint red spots on the skin
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• swelling or inflammation of the mouth
• swollen glands
• trouble breathing with exertion
• unusual bleeding or bruising
• unusual tiredness or weakness

Other side effects of talazoparib

Some side effects of talazoparib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• belching
• change or loss of taste
• decreased appetite
• diarrhea
• dizziness
• headache
• heartburn
• indigestion
• nausea
• stomach discomfort, upset, or pain
• thinning or loss of hair
• vomiting

For healthcare professionals

Applies to talazoparib: oral capsule.

General adverse events

The most reported adverse reactions have included fatigue, anemia, nausea, neutropenia, headache, thrombocytopenia, vomiting, alopecia, diarrhea, and decreased appetite.

Hematologic

• Very common (10% or more): Anemia (e.g., anemia, hematocrit decreased, hemoglobin decreased, red blood cell count decreased) (53%), neutropenia (e.g., febrile neutropenia, neutropenia and neutrophil count decreased) (35%), thrombocytopenia (e.g., thrombocytopenia, platelet count decreased) (27%), leukopenia (17%)
• Common (1% to 10%): Lymphopenia^[Ref]

Metabolic

• Very common (10% or more): Glucose increased (54%), calcium decreased (28%), decreased appetite (21%)^[Ref]

Hepatic

• Very common (10% or more): AST increased (37%), ALP increased (36%), ALT increased (33%)^[Ref]

Oncologic

• Uncommon (0.1% to 1%): Myelodysplastic syndrome, acute myeloid leukemia^[Ref]

Other

• Very common (10% or more): Fatigue/asthenia (62%)^[Ref]

Nervous system

• Very common (10% or more): Headache (33%), dizziness (17%), dysgeusia (10%)^[Ref]

Dermatologic

• Very common (10% or more): Alopecia (25%)^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (49%), vomiting (25%), diarrhea (22%), abdominal pain (19%), dyspepsia (10%)
• Common (1% to 10%): Stomatitis^[Ref]

Frequently asked questions

• What type of drug is Talzenna?

Further information

Talazoparib side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer