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Talazoparib Side Effects

Medically reviewed by Last updated on Dec 27, 2023.

Applies to talazoparib: oral capsule.

Serious side effects of Talazoparib

Along with its needed effects, talazoparib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking talazoparib:

More common

Other side effects of Talazoparib

Some side effects of talazoparib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to talazoparib: oral capsule.


The most reported adverse reactions have included fatigue, anemia, nausea, neutropenia, headache, thrombocytopenia, vomiting, alopecia, diarrhea, and decreased appetite.


Very common (10% or more): Anemia (e.g., anemia, hematocrit decreased, hemoglobin decreased, red blood cell count decreased) (53%), neutropenia (e.g., febrile neutropenia, neutropenia and neutrophil count decreased) (35%), thrombocytopenia (e.g., thrombocytopenia, platelet count decreased) (27%), leukopenia (17%)

Common (1% to 10%): Lymphopenia[Ref]


Very common (10% or more): Glucose increased (54%), calcium decreased (28%), decreased appetite (21%)[Ref]


Very common (10% or more): AST increased (37%), ALP increased (36%), ALT increased (33%)[Ref]


Uncommon (0.1% to 1%): Myelodysplastic syndrome, acute myeloid leukemia[Ref]


Very common (10% or more): Fatigue/asthenia (62%)[Ref]

Nervous system

Very common (10% or more): Headache (33%), dizziness (17%), dysgeusia (10%)[Ref]


Very common (10% or more): Alopecia (25%)[Ref]


Very common (10% or more): Nausea (49%), vomiting (25%), diarrhea (22%), abdominal pain (19%), dyspepsia (10%)

Common (1% to 10%): Stomatitis[Ref]

Frequently asked questions


1. Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group. 2018.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.