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Talzenna

Generic Name: talazoparib (TAL a ZOE pa rib)
Brand Names: Talzenna

Medically reviewed by P. Thornton, DipPharm. Last updated on Feb 11, 2019.

What is as?

See also: Kisqali

Talzenna (talazoparib) is is a prescription medicine used to treat HER2-negative breast cancer.

Talzenna is used when the cancer has spread to other parts of the body (locally advanced or metastatic).

Talzenna is used only if your cancer has a specific genetic marker (an abnormal "BRCA" gene). Your doctor will test you for this gene.

Important Information

Using Talzenna may increase your risk of developing bone marrow problems or leukemia.

Talzenna can lower your blood cell counts, and you may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, blood in your urine or stools, weight loss, fever, weakness, tiredness, or trouble breathing.

You will need weekly or monthly blood tests, and your cancer treatments may be delayed based on the results.

Before taking this medicine

To make sure Talzenna is safe for you, tell your doctor if you have ever had:

  • kidney disease.

Using Talzenna may increase your risk of developing bone marrow problems or leukemia. Ask your doctor about this risk.

You may need to have a negative pregnancy test before starting this treatment.

Talazoparib can harm an unborn baby or cause a miscarriage if the mother or the father is using this medicine.

  • If you are a woman, do not use talazoparib if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 7 months after your last dose.

  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.

  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Talzenna.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because talazoparib can harm an unborn baby.

Do not breast-feed while using this medicine, and for at least 1 month after your last dose.

How should I take Talzenna?

Take Talzenna exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

You may take Talzenna with or without food.

Swallow the capsule whole and do not dissolve or open the capsule.

If you vomit shortly after taking a dose of this medicine, do not take another dose. Wait until your next scheduled dose time to take the medicine again.

Talzenna is usually given until your body no longer responds to the medication.

Talazoparib can lower your blood cell counts, and you may get an infection or bleed more easily. You will need weekly or monthly blood tests, and your cancer treatments may be delayed based on the results.

Store at room temperature away from moisture and heat.

You should not stop using Talzenna without first asking your doctor.

Talzenna dosing information

Usual Adult Dose for Breast Cancer:

1 mg orally once a day until disease progression or unacceptable toxicity

Comments:
-Select patients based on the presence of germline BRCA mutations as determined by an FDA-approved test.

Use: For the treatment of adult patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm) HER2-negative locally advanced or metastatic breast cancer

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Talzenna?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Talzenna side effects

Get emergency medical help if you have signs of an allergic reaction to Talzenna: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • blood in your urine or stools;

  • easy bruising, unusual bleeding, purple or red spots under your skin;

  • weight loss;

  • low red blood cells (anemia) - pale skin, weakness, feeling tired or short of breath, cold hands and feet; or

  • low white blood cell counts - fever, mouth sores, skin sores, sore throat, cough, trouble breathing.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common Talzenna side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Talzenna?

Other drugs may interact with talazoparib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Talzenna only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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