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Talzenna Side Effects

Generic name: talazoparib

Medically reviewed by Last updated on Jun 9, 2022.

Note: This document contains side effect information about talazoparib. Some dosage forms listed on this page may not apply to the brand name Talzenna.

Applies to talazoparib: oral capsule.

Serious side effects of Talzenna

Along with its needed effects, talazoparib (the active ingredient contained in Talzenna) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking talazoparib:

More common

  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • chest pain
  • chills
  • cough
  • fever
  • hoarseness
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling or inflammation of the mouth
  • swollen glands
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Other side effects of Talzenna

Some side effects of talazoparib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to talazoparib: oral capsule.


The most reported adverse reactions have included fatigue, anemia, nausea, neutropenia, headache, thrombocytopenia, vomiting, alopecia, diarrhea, and decreased appetite.


Very common (10% or more): Anemia (e.g., anemia, hematocrit decreased, hemoglobin decreased, red blood cell count decreased) (53%), neutropenia (e.g., febrile neutropenia, neutropenia and neutrophil count decreased) (35%), thrombocytopenia (e.g., thrombocytopenia, platelet count decreased) (27%), leukopenia (17%)

Common (1% to 10%): Lymphopenia[Ref]


Very common (10% or more): Glucose increased (54%), calcium decreased (28%), decreased appetite (21%)[Ref]


Very common (10% or more): AST increased (37%), ALP increased (36%), ALT increased (33%)[Ref]


Uncommon (0.1% to 1%): Myelodysplastic syndrome, acute myeloid leukemia[Ref]


Very common (10% or more): Fatigue/asthenia (62%)[Ref]

Nervous system

Very common (10% or more): Headache (33%), dizziness (17%), dysgeusia (10%)[Ref]


Very common (10% or more): Alopecia (25%)[Ref]


Very common (10% or more): Nausea (49%), vomiting (25%), diarrhea (22%), abdominal pain (19%), dyspepsia (10%)

Common (1% to 10%): Stomatitis[Ref]

Frequently asked questions


1. "Product Information. Talzenna (talazoparib)." Pfizer U.S. Pharmaceuticals Group (2018):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.