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Generic Name: rucaparib (roo KAP a rib)
Brand Names: Rubraca

Medically reviewed by Last updated on Sep 3, 2019.

What is Rubraca?

Rubraca (rucaparib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Rubraca is used to treat advanced ovarian cancer.

Rubraca is used only if your tumor has a specific genetic marker, for which your doctor will test.

Rubraca is usually given after at least 2 other cancer medicines have been tried without success.

Important information

Rubraca can cause leukemia or serious bone marrow problems. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, blood in your urine or stools, shortness of breath, or signs of infection (fever, feeling weak or tired, weight loss).

Before taking this medicine

You should not use Rubraca if you are allergic to rucaparib.

Using Rubraca may increase your risk of developing serious bone marrow problems or other types of cancer, such as leukemia. Ask your doctor about your specific risk.

Do not use Rubraca if you are pregnant. It could harm the unborn baby or cause a miscarriage. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose. Tell your doctor right away if you become pregnant.

It is not known whether rucaparib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine, and for at least 2 weeks after your last dose.

How should I take Rubraca?

Take Rubraca exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Rubraca is usually taken once every 12 hours. Follow your doctor's dosing instructions very carefully.

You may take Rubraca with or without food.

If you vomit shortly after taking this medicine, do not take another dose. Wait until your next scheduled dose to take the medicine again, but do not take 2 doses at the same time.

Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.

Store at room temperature away from moisture and heat.

Rubraca dosing information

Usual Adult Dose for Ovarian Cancer:

600 mg orally twice a day
Duration of therapy: Continue treatment until disease progression or unacceptable toxicity.

-Administer each dose about 12 hours apart, with or without food.
-Select patients based on the results of the approved test for the detection of a tumor BRCA mutation in patients with ovarian cancer; the test is available at

Use: Monotherapy for treatment of patients with deleterious BRCA mutation (germline and/or somatic) associated advanced ovarian cancer who have been treated with 2 or more chemotherapies.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Rubraca?

Avoid exposure to sunlight or tanning beds. Rucaparib can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Rubraca side effects

Get emergency medical help if you have signs of an allergic reaction to Rubraca: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

  • blood in your urine;

  • shortness of breath;

  • signs of infection - fever, weight loss, feeling weak or tired; or

  • low red blood cells (anemia) - pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common Rubraca side effects may include:

  • anemia;

  • stomach pain, loss of appetite;

  • nausea, vomiting, diarrhea;

  • altered sense of taste;

  • feeling tired or short of breath;

  • abnormal liver function tests; or

  • high cholesterol.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Rubraca?

Other drugs may interact with rucaparib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Rubraca only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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