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Rubraca Side Effects

Generic Name: rucaparib

Note: This document contains side effect information about rucaparib. Some of the dosage forms listed on this page may not apply to the brand name Rubraca.

For the Consumer

Applies to rucaparib: oral tablet

Along with its needed effects, rucaparib (the active ingredient contained in Rubraca) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rucaparib:

More common
  • Black, tarry stools
  • chills
  • cough
  • fever
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • sore throat
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common
  • Bleeding gums
  • pinpoint red spots on the skin
Less common or rare
  • Bone pain
  • chest pain
  • hoarseness
  • swollen glands
Rare
  • Difficult or labored breathing
  • tightness in the chest

Some side effects of rucaparib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Dizziness
  • increased sensitivity of the skin to sunlight
  • itching or skin rash
  • lack or loss of strength
  • redness or other discoloration of the skin
  • severe sunburn
Less common
  • Abdominal or stomach pain
  • decreased appetite
  • diarrhea
  • difficulty having a bowel movement (stool)
  • nausea
  • redness, swelling, or pain of the skin
  • scaling of the skin on the hands and feet
  • tingling of the hands and feet
Rare
  • Change in taste
  • loss of taste

For Healthcare Professionals

Applies to rucaparib: oral tablet

General

-The most common adverse reactions reported in at least 20% of patients were nausea, asthenia/fatigue, vomiting, anemia, constipation, dysgeusia, decreased appetite, diarrhea, abdominal pain, dyspnea, and thrombocytopenia.
-The most common laboratory abnormalities reported in at least 35% of patients were increased creatinine, increased ALT, increased AST, decreased hemoglobin, decreased lymphocytes, increased cholesterol, decreased platelets, and decreased absolute neutrophil count.
-Adverse reactions led to dose reduction or interruption in 62% of patients (most frequently from anemia [27%] and asthenia/fatigue [22%]), and to dose discontinuation in 10% of patients (most frequently from asthenia/fatigue [2%]).[Ref]

Renal

Very common (10% or more): Increased creatinine (92%)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (77%), vomiting (46%), constipation (40%), diarrhea (34%), abdominal pain (32%)[Ref]

Other

Very common (10% or more): Asthenia/fatigue (77%), pyrexia (11%)[Ref]

Hepatic

Very common (10% or more): Increased ALT (74%), increased AST (73%)[Ref]

Hematologic

Very common (10% or more): Decreased hemoglobin (67%), decreased lymphocytes (45%), anemia (44%), decreased platelets (39%), decreased absolute neutrophil count (35%), thrombocytopenia (21%), neutropenia (15%)
Common (1% to 10%): Febrile neutropenia[Ref]

Metabolic

Very common (10% or more): Decreased appetite (39%), increased cholesterol (40%)[Ref]

Nervous system

Very common (10% or more): Dysgeusia (39%), dizziness (17%)[Ref]

Respiratory

Very common (10% or more): Dyspnea (21%)[Ref]

Dermatologic

Very common (10% or more): Dermatitis/Rash (13%), photosensitivity reaction (10%)
Common (1% to 10%): Pruritus, palmar-plantar erythrodysesthesia syndrome[Ref]

Oncologic

Uncommon (0.1% to 1%): Myelodysplastic syndrome, acute myeloid leukemia[Ref]

References

1. "Product Information. Rubraca (rucaparib)." Clovis Oncology Inc, Boulder, CO.

Some side effects of Rubraca may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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