Rubraca Side Effects

Generic name: rucaparib

Medically reviewed by Drugs.com. Last updated on Feb 19, 2023.

Note: This document contains side effect information about rucaparib. Some dosage forms listed on this page may not apply to the brand name Rubraca.

Applies to rucaparib: oral tablet.

Serious side effects of Rubraca

Along with its needed effects, rucaparib (the active ingredient contained in Rubraca) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rucaparib:

More common

Black, tarry stools
bleeding gums
bloating or swelling of the face, arms, hands, lower legs, or feet
blood in the urine
body aches or pain
chills
cough
difficulty in breathing
ear congestion
fever
headache
loss of voice
lower back or side pain
muscle aches
nasal congestion
painful or difficult urination
pale skin
pinpoint red spots on the skin
rapid weight gain
sneezing
sore throat
stuffy or runny nose
tingling of the hands or feet
trouble breathing
trouble breathing
ulcers, sores, or white spots in the mouth
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight gain or loss

Less common

Redness, swelling, or pain of the skin
scaling of the skin on the hands and feet
tenderness of the palms and soles
tingling of the hands and feet
ulceration of the skin

Other side effects of Rubraca

Some side effects of rucaparib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Belching
change in taste
constipation
decreased appetite
diarrhea
discouragement
dizziness
feeling sad or empty
heartburn
increased sensitivity of the skin to sunlight
indigestion
irritability
itching, skin rash
lack of appetite
lack or loss of strength
loss of interest or pleasure
loss of taste
nausea
redness or other discoloration of the skin
severe sunburn
stomach discomfort, upset, or pain
stomach distention
swelling or inflammation of the mouth
trouble concentrating
trouble sleeping
vomiting

For Healthcare Professionals

Applies to rucaparib: oral tablet.

General

-The most common adverse reactions reported in at least 20% of patients were nausea, asthenia/fatigue, vomiting, anemia, constipation, dysgeusia, decreased appetite, diarrhea, abdominal pain, dyspnea, and thrombocytopenia.

-The most common laboratory abnormalities reported in at least 35% of patients were increased creatinine, increased ALT, increased AST, decreased hemoglobin, decreased lymphocytes, increased cholesterol, decreased platelets, and decreased absolute neutrophil count.

-Adverse reactions led to dose reduction or interruption in 62% of patients (most frequently from anemia [27%] and asthenia/fatigue [22%]), and to dose discontinuation in 10% of patients (most frequently from asthenia/fatigue [2%]).^[Ref]

Renal

Very common (10% or more): Increased creatinine (92%)^[Ref]

Gastrointestinal

Very common (10% or more): Nausea (77%), vomiting (46%), constipation (40%), diarrhea (34%), abdominal pain (32%)^[Ref]

Other

Very common (10% or more): Asthenia/fatigue (77%), pyrexia (11%)^[Ref]

Hepatic

Very common (10% or more): Increased ALT (74%), increased AST (73%)^[Ref]

Hematologic

Very common (10% or more): Decreased hemoglobin (67%), decreased lymphocytes (45%), anemia (44%), decreased platelets (39%), decreased absolute neutrophil count (35%), thrombocytopenia (21%), neutropenia (15%)

Common (1% to 10%): Febrile neutropenia^[Ref]