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Can I take tramadol with sertraline?

Medically reviewed by Drugs.com. Last updated on April 7, 2025.

Official Answer by Drugs.com

It's best to avoid taking tramadol with sertraline as there is potential for a severe interaction. Please see link below for interaction in detail.

https://www.drugs.com/interactions-check.php?drug_list=2057-0,2221-0

Talk with your doctor or pharmacist about other safer pain relief options.

Read next

Can you take tramadol with acetaminophen, ibuprofen, or aspirin?

Yes, it is safe for most people to take tramadol with acetaminophen, ibuprofen, or aspirin if they are old enough (aspirin is not recommended for children less than 16 years and tramadol should not be taken by children under the age of 12). Continue reading

How much tramadol should I give my dog?

How much tramadol you give your dog depends on the size of your dog. Smaller dogs do not need as much tramadol as larger dogs need to relieve pain. If you give too much tramadol your dog is likely to have more severe side effects. The tramadol dosage for dogs is usually between 0.45 to 1.8 mg per pound of body weight (1mg to 5 mg/kg). The frequency varies depending on what you are giving it for. For general pain, it is given every 8 to 12 hours, but for cancer-related pain, it can be administered every 6 hours. Continue reading

How long does it take for tramadol to start working?

Tramadol generally starts to relieve pain within an hour in its fast-acting forms, which are used for short-term pain management. With slow-release or extended-release (ER) forms, the drug may take longer to start because it’s gradually released over 12 or 24 hours, but pain relief lasts longer. Continue reading

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