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Can I drink alcohol with tramadol?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Nov 2, 2022.

Official answer


No, do not drink alcohol or take any medicines that contain alcohol while using tramadol as you may overdose or die.

  • The risk of a fatal overdose is also increased when tramadol is used with other central nervous system (CNS) depressants, such as other opioids, benzodiazepines, or street drugs.
  • Extreme sedation, respiratory depression (slowed or stopped breathing), coma and death can occur.
  • Other CNS depressants also include: non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, and antipsychotics.
  • If you are not sure if you are taking a CNS depressant, ask your doctor or pharmacist before you start taking tramadol. This is not a full list of all CNS depressants.

Certain drug interactions can affect how tramadol is broken down in the body. This may increase the level of drowsiness you experience with tramadol. It is important you have your doctor or pharmacist check for drug interactions each time you start or stop taking a medicine. Tell them about all of the medicines you use, including prescription, over-the-counter, herbal and dietary supplements.

View tramadol drug interactions (in more detail)

  • Ultram [tramadol] prescribing information. US Food and Drug Administration (FDA). Revosed Oct. 2019. Accessed Nov. 12, 2020 at
  • Tramadol product monograph. Updated March 1, 2020. Accessed Nov 11, 2020 at

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