Who makes Imbruvica?
- Imbruvica is made by Pharmacyclics LLC which is a company that was acquired by AbbVie in 2015.
- Imbruvica is marketed by Abbive in the United States and by Janssen in Europe, the Middle East and Africa.
The compound that was to later become known as Imbruvica was created by scientists at Celera Genomics as a compound for studying the function of the enzyme, Bruton tyrosine kinase (BTK).
In 2006, Pharmacyclics acquired the compound alongside a few other development programs, and renamed the compound PCI-32765.
In 2011 after the drug had completed Phase II trials, Pharmacyclics and Johnson & Johnson agreed to co-develop the drug, and J&J paid Pharmacyclics $150 million upfront and $825 million in milestones.
In 2015, Pharmacyclics was acquired by AbbVie in May 2015 for $21 million, and currently, Imbruvica is co-marketed by Janssen – a pharmaceutical company belonging to Johnson & Johnson; and Abbvie.
The Pharmacyclics name was retained, and it operates as a subsidiary of AbbVie from its previous Sunnyvale, California, headquarters.
Janssen markets Imbruvica in Europe, the Middle East and Africa and AbbVie markets it in the United States.
In 2018, Imbruvica generated a total of $5.6 billion for Janssen and AbbVie and is forecast to generate $11.9 billion in 2025.
References
- Imbruvica (ibrutinib) capsules [Package Insert] Pharmacyclics LLC, an AbbVie Company and Janssen Biotech, Inc https://www.drugs.com/pro/imbruvica.html
- Janssen and AbbVie’s Imbruvica earns approval in two new settings from the EC Pharmaceutical-Technology 08/2019 https://www.pharmaceutical-technology.com/comment/janssen-and-abbvie-imbruvica-2019/
Read next
How much does Imbruvica cost?
According to the Drugs.com price guide which bases its price on the Drugs.com discount card which is accepted at most U.S. pharmacies, the cost for Imbruvica 420mg tablet is around $616 per tablet or $17 269 for a supply of 28 tablets depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans. Continue reading
How long can you stay on Imbruvica (ibrutinib)?
Imbruvica (ibrutinib) is usually continued indefinitely if it is being well tolerated, there is limited disease progression, and toxicity has not occurred. Continue reading
Can ibrutinib be stopped safely?
Stopping ibrutinib can result in a disease flare-up in patients with chronic lymphocytic leukemia (CLL). A 2020 study in The Oncologist found that approximately 25% of ibrutinib patients with a median interruption period of 8 days experienced a flare or rapid CLL progression. Continue reading
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