How is Yescarta administered?
Yescarta (axicabtagene ciloleucel) is given through a catheter placed into your vein (intravenous infusion), typically in your arm. The infusion usually takes less than 30 minutes. It is given as a one-time infusion. It is a special infusion made just for you using your own white blood cells in a process called “leukapheresis” which will concentrate your white blood cells to help fight cancer.
Before you get Yescarta, you will get 3 days of chemotherapy to prepare your body. After the Yescarta infusion, you will be monitored daily for at least 7 days.
You will need to remain close-by to a healthcare facility for at least 2 weeks after receiving Yescarta. Your healthcare providers will monitor you for side effects.
If side effects become serious after discharge, you may need to be readmitted to a healthcare facility for monitoring. Your healthcare provider will discharge you if your side effects are under control, and it is safe for you to leave the hospital.
Your healthcare provider will want to do blood tests to follow your progress, and these tests are important. If you miss an appointment, call your doctor to reschedule right away.
Avoid driving for at least 2 weeks after you get Yescarta. Do not donate blood, organs, tissues, or cells for transplantation.
Read more about Yescarta at: Important Yescarta warnings and side effects
What is Yescarta approved for?
- Yescarta (axicabtagene ciloleucel), from Kite Pharma, is a chimeric antigen receptor T cell (CAR T) therapy used for adults with large B-cell lymphoma or follicular lymphoma (FL) after failing at least two other systemic treatments. Large B-cell lymphoma and follicular lymphoma are two types of non-Hodgkin lymphoma.
- It is also approved for patients with large B-cell lymphoma who are refractory (have not responded) to first-line chemoimmunotherapy or that relapse (cancer returns) within 12 months of first-line chemoimmunotherapy.
- The use for follicular lymphoma is approved under FDA accelerated approval based on response rate. Continued approval for this indication may depend upon the clinical benefit seen in confirmatory trials.
Yescarta is a biologic-type drug which is manufactured specifically for each patient from their own white blood cells. The receipt of CAR T-cell therapy is a one-time procedure, and the CAR-T cells may continue to replicate in the body to fight the cancer.
Related questions
- What is the cost of Yescarta?
- What's the difference between Kymriah and Yescarta?
- What type of drug is Yescarta (axicabtagene ciloleucel)?
How is Yescarta made in the lab?
Here's the general step-by-step process for CAR T-cell development:
- First, leukapheresis (loo-kah-fur-ee-sis), a procedure to collect the patient's white blood cells (lymphocytes), is performed in the hospital, and then the T-cells are isolated. The T-cells are white blood cells used for immune responses.
- The T-cells are sent to lab where they are genetically engineered to construct a chimeric antigen receptor (CAR) on the cell surface.
- Genes are inserted into the T-cells using an inactive virus which allows the CAR T-cell to recognize, activate, and kill the lymphoma cells.
- The CAR T-cell is grown in the lab for about 2 weeks to greatly increase the dose. The cells are frozen and then sent to the hospital for re-infusion to the patient.
- In the mean time, the patient will receive 3 days of chemotherapy to help lower the white blood cell count and allow the CAR T-cells to be better accepted by the body.
This is not all the information you need to know about Yescarta (axicabtagene ciloleucel) for safe and effective use and does not take the place of your doctor's directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.
References
- Yescarta (axicabtagene ciloleucel). Product Information. Revised June 2025. Kite Pharma, Inc. Santa Monica, CA. Accessed July 3, 2025 at https://www.gilead.com/-/media/files/pdfs/medicines/oncology/yescarta/yescarta-pi.pdf
Read next
What is the difference between Truxima and Rituxan?
Truxima (rituximab-abbs) is a biosimilar to Rituxan (rituximab). While both drugs are CD20-directed cytolytic antibodies used to treat non-Hodgkin’s lymphoma (NHL), Rituxan has additional FDA-approved indications beyond NHL. Continue reading
What is the success rate of Rituxan (rituximab) in patients with blood cancers?
In patients with hematological or blood cancers, including non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL), Rituxan’s success is measured in a number of ways. It is measured by looking at how long patients responded to treatment (median duration of response), how long they live without their disease progressing (progression-free survival) and how many patients respond to treatment (response rate).
Rituxan treatment improves outcomes in certain patients with NHL. Adding Rituxan alongside standard therapies enhances the response patients have to treatment and improves overall outcomes, including increasing the time patients live for without experiencing a progression of their disease.
Rituxan helps to improve overall survival in certain patients with CLL and also helps to increase the time patients live for without experiencing disease progression. Adding Rituxan alongside standard therapy enhances the response patients have to therapy. Continue reading
Does Truxima make you gain weight?
Weight gain has been reported in 11% of patients being treated with Truxima (rituximab) for non-Hodgkin’s lymphoma (NHL). Be sure to contact your doctor right away if you have a rapid or unexplained weight gain or fluid retention (edema), nausea, vomiting, diarrhea, or lack of energy when using Truxima, as you may need immediate medical care. Continue reading
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