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How is Rituxan Hycela administered?

Medically reviewed by Nicole France, BPharm. Last updated on Sep 29, 2021.

Official answer


Rituxan Hycela (rituximab and hyaluronidase human) is given via subcutaneous injection - an injection under the skin - in the stomach area. It is administered by a healthcare professional.

Rituxan Hycela contains rituximab, the same active ingredient as in Rituxan. But it has been formulated so that it can be given over 5-7 minutes via subcutaneous injection, rather than via intravenous (IV) infusion like Rituxan, which can take 3-6 hours.

Rituxan Hycela should only be administered after at least one full dose of a rituximab product has been administered via intravenous (IV) infusion because of the potential for hypersensitivity reactions and other side effects during the initial administration of rituximab products.

Before you receive Rituxan Hycela, an antihistamine and acetaminophen, and possibly a glucocorticoid medication, will be administered to help prevent side effects. After your injection you’ll be monitored for at least 15 minutes.


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