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Is Genvoya better than Stribild?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Aug 13, 2020.

What is the difference between Genvoya and Stribild?

Official Answer

by Drugs.com

Is Genvoya better than Stribild?

Yes, Genvoya was designed as a new and improved version of Stribild, it has a similar clinical effect on HIV but a better safety profile.


What is the difference between Genvoya and Stribild?

Genvoya and Stribild are both four-drug HIV medications, they have three ingredients the same
(cobicistat 150mg, elvitegravir 150mg, emtricitabine 200mg).
For the fourth ingredient:

  • Genvoya has tenofovir alafenamide (TAF) 10mg and
  • Stribild has tenofovir disoproxil fumerate (TDF) 300mg.


Stribild was the first of these two medicines to be approved by the FDA on 27 August 2012.
Genvoya was approved on 5 November 2015.

Why did they change tenofovir disoproxil fumerate (TDF) to tenofovir alafenamide (TAF) for Genvoya?

  • Tenofovir disoproxil fumerate, which is one of the ingredients in Stribild, can have side effects of being toxic to the kidneys and can reduce bone density.
  • To overcome this issue Genvoya was developed which replaced tenofovir disoproxil fumerate with tenofovir alafenamide which has improved safety for kidney and bones.
  • Genvoya had the same clinical effect as Stribild but had better kidney and bone safety when compared to Stribild.

Bottom line:

  • Genvoya was designed to have the same clinical effect against HIV as Stribild, but have improved renal and bone safety when compared to Stribild.
  • Genvoya contains tenofovir alafenamide (TAF) 10mg with cobicistat 150mg, elvitegravir 150mg and emtricitabine 200mg
  • Stribild contains tenofovir disoproxil fumarate (TDF) 300mg with cobicistat 150mg, elvitegravir 150mg and emtricitabine 200mg


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