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Clobex Spray, Lotion & Shampoo - Which one do I use?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Nov 20, 2024.

Official Answer by Drugs.com

Key Points

Clobex (clobetasol propionate) 0.05% is a super-high potent topical corticosteroid available as a prescription spray, lotion and shampoo. Clobex Spray is used to treat plaque psoriasis on the skin and Clobex Shampoo treats scalp psoriasis. Clobex Lotion is approved to treat the swelling and itching due to certain skin conditions such as atopic dermatitis (eczema) and plaque psoriasis.

Lotions and sprays are often more acceptable for use on the skin and hard-to-reach areas, while shampoos work well on the scalp.

How do I use Clobex?

Always follow your doctor’s directions for dosing and length of time to treat your skin or scalp condition. Do not exceed the prescribed dose as it may increase the risk for severe side effects. Read the patient medication guide each time you get a prescription. If you have questions, ask your doctor or pharmacist.

Clobex Spray 0.05% is approved to treat moderate to severe plaque psoriasis affecting up to 20% of your body surface area (BSA).

Clobex Lotion 0.05% is used for certain skin conditions such as atopic dermatitis and psoriasis (known as corticosteroid-responsive dermatoses).

Clobex Shampoo 0.05% is used to treat moderate to severe forms of scalp psoriasis.

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Bottom Line

Clobex Spray 0.05% is used to treat psoriasis on the skin and Clobex Shampoo 0.05% treats scalp psoriasis. Clobex Lotion 0.05% is also approved to treat psoriasis, in addition to other skin conditions such as eczema. Clobex topical treatments are used only in patients 18 years of age or older.

Always follow your doctor’s directions for dosing and length of time to treat your skin or scalp condition. Do not exceed the prescribed dose as it may increase the risk for severe side effects.

This is not all the information you need to know about Clobex (clobetasol propionate 0.05%) Topical Spray, lotion or shampoo for safe and effective use. Review the full Clobex information, and discuss this information and any questions you have with your doctor or other health care provider.

References

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Does clobetasol cause hair loss or growth?

Clobetasol can stimulate hair growth. Regrowth may be noticed as early as six weeks into treatment but may take up to 12 to 14 weeks to occur. In some people, hair regrowth does not persist long-term. Clobetasol should only be used for hair loss associated with inflammatory conditions of the scalp such as alopecia areata, scarring alopecia, psoriasis, eczema, or dermatitis. Hair loss or hair thinning may also occur, but this is a very rare side effect and is estimated to occur in only 1 out of every 300 people who use clobetasol. Clobetasol is a potent topical steroid and is not a good option for hair and scalp conditions that are not associated with inflammation. Continue reading

How long does it take for clobetasol propionate to work?

It takes about one to three days for clobetasol propionate to start working when it is being used to treat eczema. Some improvement in symptoms such as inflammation (redness) and itching, should be noticed within this time. Other symptoms, such as dryness, crusting, or scaling may take a bit longer to resolve, but improvement should occur within a week. Continue reading

Clobetasol vs. triamcinolone - how do they compare?

Topical clobetasol (Clobex, Impoyz, generics) is considered a very high potency topical corticosteroid (“steroid”) used on the skin, while triamcinolone (Kenalog, Triderm, generics) is a medium-to-low potency medicine. These prescription products may be used to treat conditions such as eczema, dermatitis, psoriasis, skin allergies or rashes or serious insect bites. Continue reading

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