Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- ceftobiprole medocaril
- Olysio (simeprevir)
Interactions between your drugs
ceftobiprole simeprevir
Applies to: ceftobiprole medocaril, Olysio (simeprevir)
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Coadministration with ceftobiprole may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of organic anion transporting polypeptide (OATP) 1B1 and/or OATP1B3. The proposed mechanism is decreased clearance due to ceftobiprole-mediated inhibition of OATP1B1 and/or OATP1B3.
MANAGEMENT: Concomitant use of ceftobiprole with drugs that are substrates of OATP1B1 and/or OATP1B3 is not recommended. Clinical and laboratory monitoring may be appropriate whenever ceftobiprole is added to or withdrawn from therapy with these drugs. Dosage adjustments may be considered if an interaction is suspected. Patients should be monitored for the development of adverse effects.
Drug and food interactions
simeprevir food
Applies to: Olysio (simeprevir)
Food significantly increases the absorption of simeprevir. You should take each dose of simeprevir with food. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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