Generic Name: simeprevir (sim E pre vir)
Brand Names: Olysio
What is Olysio?
Olysio (simeprevir) is an antiviral medicine that prevents certain viruses from multiplying in your body.
Olysio is used in combination with peginterferon alfa and ribavirin, or with sofosbuvir to treat hepatitis C genotype 1 or 4 in adults.
Read the medication guide or patient instructions provided with Olysio and the other medications in your combination therapy. Do not change your doses or medication schedule without your doctor's advice. Every person with hepatitis C should remain under the care of a doctor.
Olysio is used in combination with other medications. Read the medication guide or patient instructions provided with each medication in your combination therapy. Do not change your doses or medication schedule without your doctor's advice.
If you have ever had hepatitis B, simeprevir can cause this condition to come back or get worse. You will need frequent blood tests to check your liver function.
Call your doctor right away if you have symptoms of liver problems: vomiting, loss of appetite, feeling weak or tired, clay-colored stools, or jaundice (yellowing of the skin or eyes).
If you take simeprevir with sofosbuvir and amiodarone, call your doctor or get emergency medical help if you have: slow heartbeats, chest pain, extreme weakness, confusion, memory problems, and feeling light-headed or short of breath.
Avoid exposure to sunlight or tanning beds. Sunlight can cause a severe rash or skin reaction while you are using Olysio combination treatment. Use sunscreen and wear a hat, sunglasses, and protective clothing when you are outdoors.
Do not use Olysio with peginterferon alfa and ribavirin if you are pregnant, or if you are a man and your female sexual partner is pregnant. Ribavirin can cause birth defects or death in an unborn baby.
Before taking this medicine
You should not use Olysio if you are allergic to simeprevir.
Your doctor will perform blood tests to make sure simeprevir is the right treatment for your condition.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
liver problems other than hepatitis, or if you have had a liver transplant; or
if you are receiving phototherapy (light therapy).
Olysio is sometimes used in combination with ribavirin. Ribavirin can cause birth defects or death in an unborn baby. You may need to have a negative pregnancy test before using these medications together, and every month during your treatment.
If you are a woman, do not use ribavirin if you are pregnant.
If you are a man, do not use ribavirin if your sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking ribavirin.
Use at least 2 effective forms of birth control while either sexual partner is using ribavirin. Keep using 2 forms of birth control for at least 6 months after treatment ends. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Olysio with ribavirin.
It is not known whether simeprevir passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Olysio is not approved for use by anyone younger than 18 years old.
How should I take Olysio?
Take Olysio exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Olysio must be given in combination with other antiviral medications and it should not be used alone.
Take with food.
Do not crush, chew, break, or open a Olysio capsule. Swallow the capsule whole.
You will need frequent blood tests to check your liver function.
Read the medication guide or patient instructions provided with each medication in your combination therapy. Do not change your doses or medication schedule without your doctor's advice. Every person with chronic hepatitis C should remain under the care of a doctor.
You should not stop using this medicine suddenly. Stopping suddenly could make your condition harder to treat with hepatitis C antiviral medicine.
If you have ever had hepatitis B, Olysio can cause this condition to come back or get worse. You will need liver function tests during treatment and for several months after you stop using this medicine.
Store at room temperature away from moisture, heat, and light.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. If you are more than 12 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Olysio?
Avoid exposure to sunlight or tanning beds. Olysio combination treatment can make your skin more sensitive to sunlight, especially during the first 4 weeks of treatment. This may cause a severe sunburn or skin rash. Wear a hat, sunglasses, and protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Avoid taking an herbal supplement containing St. John's wort at the same time you are taking simeprevir.
Olysio side effects
Get emergency medical help if you have signs of an allergic reaction to Olysio: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Read all of your medication guides to learn about possible side effects of other medications you use in combination with simeprevir. Ask your doctor or pharmacist if you have any questions.
If you take Olysio with sofosbuvir and amiodarone, call your doctor or get emergency medical help if you have: slow heartbeats, chest pain, extreme weakness, confusion, memory problems, and feeling light-headed or short of breath.
Call your doctor at once if you have:
new or worsening liver symptoms, such as vomiting, loss of appetite, feeling weak or tired, clay-colored stools, or yellowing of the skin or eyes;
severe skin rash (redness, swelling, burning, blistering);
eye redness or puffiness;
shortness of breath; or
(if you also take amiodarone) - confusion, chest pain, extreme weakness or drowsiness, feeling like you might pass out.
Your treatment with Olysio may be permanently discontinued if you have certain side effects.
Common Olysio side effects may include:
mild itching or rash;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Olysio?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Taking Olysio together with sofosbuvir and amiodarone (a heart rhythm medication) may slow your heart rate which can lead to serious medical problems. Tell your doctor if you take amiodarone (Cordarone, Nexterone, Pacerone).
Other drugs may interact with simeprevir, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
More about Olysio (simeprevir)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 4 Reviews – Add your own review/rating
- Drug class: protease inhibitors
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about Olysio.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Olysio only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2017 Cerner Multum, Inc. Version: 2.01.
Date modified: July 02, 2017
Last reviewed: May 30, 2017