Drug Interaction Report

Consumer information for this interaction is not currently available.

MONITOR: Methylphenidate and other derivative amphetamines may decrease the therapeutic effects of antihypertensive drugs or agents with hypotensive properties. According to serdexmethylphenidate label information, CNS stimulants cause a mean increase in blood pressure of approximately 2 to 4 mmHg and a mean increase in heart rate of approximately 3 to 6 beats per minute. With some individuals having larger increases.

MANAGEMENT: Caution and monitoring of blood pressure is recommended if methylphenidate, dexmethylphenidate or serdexmethylphenidate are administered with antihypertensives agents such as: potassium-sparing and thiazide diuretics, calcium channel blockers, angiotensin-converting-enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), beta blockers or centrally acting alpha-2 receptor agonists. The dosage of the antihypertensive drug should be adjusted as needed.

Both dexmethylphenidate and serdexmethylphenidate can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Consumer information for this interaction is not currently available.

MONITOR: Methylphenidate and other derivative amphetamines may decrease the therapeutic effects of antihypertensive drugs or agents with hypotensive properties. According to serdexmethylphenidate label information, CNS stimulants cause a mean increase in blood pressure of approximately 2 to 4 mmHg and a mean increase in heart rate of approximately 3 to 6 beats per minute. With some individuals having larger increases.

MANAGEMENT: Caution and monitoring of blood pressure is recommended if methylphenidate, dexmethylphenidate or serdexmethylphenidate are administered with antihypertensives agents such as: potassium-sparing and thiazide diuretics, calcium channel blockers, angiotensin-converting-enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), beta blockers or centrally acting alpha-2 receptor agonists. The dosage of the antihypertensive drug should be adjusted as needed.