Landiolol

Generic name: landiolol
Brand name: Rapiblyk
Drug classes: Cardioselective beta blockers, Group II antiarrhythmics

Medically reviewed by Drugs.com on May 6, 2025. Written by Cerner Multum.

What is landiolol?

Landiolol is used in adults to help keep the heart beating normally in people with certain heart rhythm disorders, such as atrial fibrillation or atrial flutter.

Landiolol may also be used for purposes not listed in this medication guide.

Landiolol side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Tell your medical caregivers at once if you have:

• feeling like you might pass out;

• new or worsening chest pain;

• slow or fast heartbeats;

• severe headache, blurred vision, pounding in your neck or ears;

• bronchospasm (wheezing, chest tightness, trouble breathing);

• pain, swelling, redness, burning, blisters, skin sores, or irritation around the IV needle;

• cold feeling in your hands and feet;

• heart problems--swelling, rapid weight gain, feeling short of breath;

• high blood potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or

• low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery.

Common side effects of landiolol may include:

• low blood pressure.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

You should not use landiolol if you have a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), severe heart failure, pulmonary hypertension, slow heartbeats that have caused you to faint, recently had a heart attack, or if you are receiving certain IV heart or blood pressure medications.

Before taking this medicine

You should not receive landiolol if you are allergic to it, or if you have:

• a serious heart condition such as "sick sinus syndrome" or "AV block" (second or third degree);

• pulmonary hypertension (increased pressure inside the blood vessels of the lungs and heart);

• severe heart failure;

• history of slow heart beats that have caused you to faint;

• if you have recently had a heart attack; or

• a condition for which you are being treated with intravenous (IV) heart or blood pressure medication (such as diltiazem, nicardipine, or verapamil).

Tell your doctor if you have or have ever had:

• a certain type of chest pain (Prinzmetal's angina);

• asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder;

• diabetes (taking landiolol may make it harder for you to tell when you have low blood sugar);

• congestive heart failure, low blood pressure, or coronary artery disease (hardened arteries);

• pheochromocytoma (tumor of the adrenal gland);

• high blood levels of potassium (hyperkalemia);

• if your heart cannot pump blood properly;

• overactive thyroid;

• metabolic acidosis;

• any allergies;

• peripheral vascular disease such as Raynaud's syndrome; or

• liver or kidney disease.

Tell your doctor if you are pregnant or breastfeeding.

How is landiolol given?

Follow all directions on your prescription label and read all medication guides or instruction sheets.

Landiolol is given as an infusion into a vein. A healthcare provider will give you this injection.

Tell your medical caregivers if you feel any burning or pain when landiolol is injected.

Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving landiolol.

Your blood pressure will need to be checked often and you may need medical tests to check your progress. Your blood sugar and heart function will also be checked on a regular basis.

Landiolol dosing information

Usual Adult Dose for Supraventricular Tachycardia:

Normal Cardiac Function:
-Starting dose: 9 mcg/kg/min IV
-Titration interval: 10 minutes
-Titration step: 9 mcg/kg/min IV
-Maximum dose: 36 mcg/kg/min IV

Impaired Cardiac Function:
-Starting dose: 1 mcg/kg/min IV
-Titration interval: 15 min
-Titration step: 1 mcg/kg/min IV
-Maximum dose: 36 mcg/kg/min IV

Comments:
-This drug is administered as a continuous IV infusion, titrating as needed for heart rate control.
-Limited data are available beyond 24 hours of use.
-The infusion rate can be calculated as: Infusion rate (mL/hour) = target dose (mcg/kg/min) multiplied by body weight (kg) divided by 93

Use: For the short-term reduction of ventricular rate in patients with supraventricular tachycardia (including atrial fibrillation and atrial flutter)

What happens if I miss a dose?

In a medical setting you are not likely to miss a dose.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving landiolol?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect landiolol?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Tell your doctor about all your other medicines, especially:

• reserpine;

• an MAO inhibitor--isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others;

• digoxin;

• heart or blood pressure medication; or

• medicines to treat asthma, colds, or allergies.

This list is not complete. Other drugs may affect landiolol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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