Drug Interaction Report

Lefamulin may alter the blood levels thiotepa which may make it less effective in treating your cancer. You may also have increased side effects such as nausea, vomiting, mouth ulcers, skin conditions, and low blood cell counts, which can make you more likely to develop anemia, bleeding problems, and infections. Your doctor may already be aware of the risks but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you more closely. Contact your doctor if you experience potential signs and symptoms of these conditions such as paleness of skin, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, or other flu-like symptoms. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

The following interaction applies only if you are taking lefamulin (Xenleta) orally:

Food may interfere with the absorption of lefamulin, which may lead to lower blood levels of the medication and possibly reduced effectiveness. You should take lefamulin at least 1 hour before or 2 hours after a meal. It is best to avoid or limit the consumption of grapefruit and grapefruit juice during treatment with lefamulin, as it may increase blood levels of the medication and increase side effects. Talk to your doctor or pharmacist if you have any questions or concerns.