Drug Interaction Report

Ceritinib may increase the absorption of vilanterol from the lungs into the blood stream. You may be more likely to experience cardiovascular side effects such as palpitation, chest pain, irregular heart beat, increased heart and pulse rates, and blood pressure elevations. Talk to your doctor before using these medications if you have a history of heart disease or high blood pressure, or if you have other questions or concerns. The risk of side effects also increases with overuse of vilanterol. Therefore, you should not exceed the dose or frequency of use prescribed by your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Do not consume grapefruit or grapefruit juice during treatment with ceritinib unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of ceritinib to dangerous levels, increasing the risk of an irregular heart rhythm that may be serious. Other, more common side effects such as diarrhea, nausea, vomiting, abdominal pain, and hyperglycemia (high blood sugar) may also increase. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with ceritinib. Food may also increase the blood levels of ceritinib. Therefore, you should take ceritinib on an empty stomach, meaning no food should be eaten for at least two hours before or after taking ceritinib. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.