Drug Interaction Report

Before you undergo surgery where anesthesia with propofol may be given, let your doctor know if you are currently being treated with ezogabine. In studies with rats, ezogabine has been shown to prolong the sleep time induced by propofol. Studies have not been performed in human. You may need to be monitored more closely during anesthesia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Alcohol can increase the nervous system side effects of propofol such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with propofol. Do not use more than the recommended dose of propofol, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Alcohol can increase the blood levels of ezogabine and worsen side effects such as drowsiness, dizziness, nausea, constipation, difficulty urinating, blurred vision, memory impairment, and tremor. You should avoid or limit the use of alcohol while being treated with ezogabine. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Ezogabine may be taken with or without food. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.