Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- aprotinin
- Bebulin VH (factor ix complex)
Interactions between your drugs
aprotinin factor IX complex
Applies to: aprotinin, Bebulin VH (factor ix complex)
GENERALLY AVOID: Due to additive or synergistic pharmacodynamic effects, the risk of thrombosis may be increased when antifibrinolytic agents (e.g., aminocaproic acid, aprotinin, tranexamic acid) are coadministered with other hemostatic agents such as factor VIII inhibitor bypassing fraction, factor IX complex, prothrombin complex, or direct oral anticoagulant reversal agents.
MANAGEMENT: Concomitant administration of antifibrinolytic agents with other hemostatic agents should generally be avoided. Consult the manufacturer's product labeling for recommended dosing intervals between products.
References (4)
- (2001) "Product Information. Amicar (aminocaproic acid)." Immunex Corporation
- (2001) "Product Information. Cyklokapron (tranexamic acid)." Pharmacia and Upjohn
- (2022) "Product Information. Lysteda (tranexamic acid)." Xanodyne Pharmaceuticals Inc
- (2023) "Product Information. Tranexamic Acid (tranexamic acid)." Armas Pharmaceuticals, Inc.
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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