Methotrexate Interactions
There are 727 drugs known to interact with methotrexate, along with 5 disease interactions, and 3 alcohol/food interactions. Of the total drug interactions, 145 are major, 567 are moderate, and 15 are minor.
- View all 727 medications that may interact with methotrexate
- View methotrexate alcohol/food interactions (3)
- View methotrexate disease interactions (5)
Most frequently checked interactions
View interaction reports for methotrexate and the medicines listed below.
- Celebrex (celecoxib)
- Celebrex (celecoxib)
- Cymbalta (duloxetine)
- Cymbalta (duloxetine)
- Enbrel (etanercept)
- Enbrel (etanercept)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Humira (adalimumab)
- Humira (adalimumab)
- Lyrica (pregabalin)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Succinate ER (metoprolol)
- Plaquenil (hydroxychloroquine)
- Plaquenil (hydroxychloroquine)
- Singulair (montelukast)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Vitamin D3 (cholecalciferol)
- Zyrtec (cetirizine)
- Zyrtec (cetirizine)
Methotrexate alcohol/food interactions
There are 3 alcohol/food interactions with methotrexate.
Methotrexate disease interactions
There are 5 disease interactions with methotrexate which include:
Report options
More about methotrexate
- methotrexate consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (338)
- Drug images
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: antimetabolites
- Breastfeeding
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Stelara
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Enhertu
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Cosentyx
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
