Krokodil Drug Facts
Medically reviewed on Aug 21, 2018 by L. Anderson, PharmD
Common or street names: Crocodile, Russian Magic, Poor Man's Heroin, Zombie drug
What is krokodil (desomorphine)?
Desomorphine, known by the street name krokodil, is an opioid derivative of codeine. Like heroin and other opioids, it has a sedative and analgesic effect and is highly addictive. Those who inject these caustic agents into their veins can develop extreme skin ulcerations, infections, and gangrene -- a discolored (green, grey, black) scale-like skin that resembles a crocodile, hence the street name “krokodil”. Krokodil is also called “Russian Magic”, referring to its short duration of opioid intoxication (euphoria).
Krokodil is reported to contain desomorphine, a synthetic morphine analogue synthesized in the 1930s. Due to illicit, home-based manufacturing it may contain other unknown ingredients. It is typically abused via the intravenous route. Desomorphine is a Schedule I substance in the U.S., meaning it has high abuse potential with no accepted medical use.
Homemade versions of the drug start with codeine, and can be ‘cooked’ similar to illicit methamphetamine (“meth”) production. Organic solvents such as gasoline, paint thinner, or lighter fluid, iodine, hydrochloric acid, and red phosphorus (from matches) are used in homemade synthesis. These dangerous chemicals are not always fully “cooked” out of the concoction when used to make illicit krokodil. Krokodil also refers to chlorocodide, a codeine derivative in the synthetic path to desomorphine.
What are the side effects of krokodil?
According to reports, the drug is fast-acting within 2 to 3 minutes and 10 to 15 times more potent than morphine, and three times as toxic. In fact, when the toxic chemicals are removed, quite often what is left is desomorphine, a compound very similar to heroin. After a rapid onset, the euphoric effects may last less than two hours. Due to the short duration of the “high”, many users find themselves in a rapid repetition of drug use to avoid withdrawal symptoms that resemble heroin. Due to the drug’s rapid onset but short duration of action and frequent administration, quick physical dependence may occur.
There have been multiple unconfirmed news reports of users in the U.S. who have had extreme skin ulcerations, infections and scale-like skin due to use of krokodil. Indeed, the most common complications reported thus far from krokodil injection appears to be the serious vein damage, soft tissue infections, necrosis and gangrene. According to reports, the localized soft tissue effects occur relatively quickly after the use of krokodil. There have been news reports of amputations. It appears that ulcerations may occur locally at the drug injection site or also at remote areas of the body. There may be further organ or central nervous system damage.
Reported health hazards due to krokodil injection use include:
- Blood vessel damage (thrombophlebitis)
- Open ulcers, gangrene
- Skin and soft tissue infections
- Need for skin grafts and surgery
- Limb amputations
- Blood poisoning
- Rotting gums or tooth loss
- Blood-borne virus transmission (HIV and HCV due to needle sharing)
- Bone infections (osteomyelitis) and osteonecrosis
- Speech and motor skills impairment
- Memory loss and impaired concentration
- Liver and kidney damage
- Powerful respiratory depressant effect
Animal studies in rats have demonstrated cardiac congestion, necrosis at the injection site, and kidney toxicity.
What is the extent of krokodil use?
Krokodil has been synthesized in Russia for over a decade. About one million people in Russia use krokodil according to the New York State Office of Alcoholism and Substance Abuse Services. Krokodil goes by the names of “Cheornaya” in Russia and “Himiya” in Ukraine. According to the head of the Russian Federal Drug Control Service, the amount of krokodil seized in Russia increased 23-fold between 2009 and 2011. Krokodil has also been reported in other countries including the Ukraine, Georgia, Kazakhstan, Germany and Norway.
Previously in Russia and Ukraine, Afghan heroin was the drug of choice when making homemade injectables. Due to a possible Afghan opium crop fungal disease in 2010, the production of opium was 48 percent lower than the previous year. Therefore, in Eurasia, users turned to over-the-counter medications that contain codeine for pain or cough (e.g. Solpadeine, Codterpin or Codelac) as an ingredient for krokodil. Codeine is preferred instead of heroin because of lower costs and ease of availability. However, the medications combined with the codeine such as acetaminophen or terpin hydrate, their effect on the chemical reactions, and their ultimate contribution to the toxicity of krokodil are all unknown. In some former Soviet Union regions, officials attribute at least half of all drug-related deaths due to krokodil.
In the U.S., codeine is a controlled substance and either requires a prescription or may be available over-the-counter from the pharmacist (as with some cough syrups) with restrictions in some states. There were few reports of krokodil use in the U.S. until September 2013 when a poison control center in Phoenix, Arizona received inquiries about the product. Additional reports have surfaced from Illinois and Oklahoma. However, as of October 2013, the U.S. Drug Enforcement Agency (DEA) has stated that they are skeptical that krokodil has crossed American borders. The DEA notes that they have not seen any cases of it, and nothing has been turned into their laboratories. To have official confirmation, the DEA would require a drug sample. Users in America may unknowingly buy krokodil off the streets under the assumption they are buying heroin.
Is krokodil addictive?
Addiction is an obvious problem with krokodil use due to its high opioid potency and short duration of effect. Frequent administration may lead to binge patterns that can last for days. Users are at increased risk for exhaustion due to sleep deprivation, memory loss, and problems with speech. Variations in potency or "homemade" recipes can put users at increased risk of overdose.
According the the DEA, repeated administration of desomorphine with short intervals in cancer patients with severe pain showed that desomorphine produced a high degree of addiction liability.
Another less obvious risk with krokodil use is that those who are afflicted with gangrene and other side effects may delay seeking much-needed medical treatment due to fear of legal action. In addition, the desire for continued krokodil administration to prevent withdrawal effects may prevent users from presenting for treatment.
- Bath Salts
- Devil's Breath
- Gray Death
- PCP (Phencyclidine)
- Psilocybin (Magic Mushrooms)
- Speed (methamphetamine)
- Synthetic Marijuana (Spice or K2)
- TCP (Tenocyclidine)
- U-47700 (Pink)
- Alves EA, Brandao P, Neves JF, et al. Repeated subcutaneous administrations of krokodil causes skin necrosis and internal organs toxicity in Wistar rats: putative human implications. Hum Psychopharmacol. 2017 May;32(3). doi: 10.1002/hup.2572. Accessed August 21, 2018 at https://www.ncbi.nlm.nih.gov/pubmed/28657190
- Florez DH, Dos Santos Moreira AM, da Silva PR, et al. Desomorphine (Krokodil): An overview of its chemistry, pharmacology, metabolism, toxicology and analysis. Drug Alcohol Depend. 2017 Apr 1;173:59-68. doi: 10.1016/j.drugalcdep.2016.12.021. Epub 2017 Jan 31. Accessed August 21, 2018 at https://www.ncbi.nlm.nih.gov/pubmed/28199917
- Facts about Krokodil (the “Zombie Drug”). DrugAbuse.com. Accessed August 21, 2018 at https://drugabuse.com/library/krokodil-drug/
- Desomorphine. Drug Enforcement Agency (DEA). Accessed August 21, 2018 at https://www.deadiversion.usdoj.gov/drug_chem_info/desomorphine.pdf
- Grunda JC, Latypovc A, Harris M. Breaking worse: The emergence of krokodil and excessive injuries among people who inject drugs in Eurasia. International Journal of Drug Policy 2013:24; 265–74. Accessed July 7, 2014. http://www.idhdp.com/mediaimport/41793/inj_damage_from_krokodil_in_eurasia.pdf
- Drugs.com. Health Highlights. September 27, 2013. Accessed October 17, 2013.
- CNN. Christensen J. Flesh-eating 'zombie' drug 'kills you from the inside out. October 16, 2013. Accessed October 17, 2013. http://www.cnn.com/2013/10/16/health/krokodil-zombie-drug/
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