Medically reviewed on Aug 31, 2018 by L. Anderson, PharmD
Generic Name: Lysergic acid diethylamide (LSD)
Common or street names: LSD is sold under more than 80 street names including Acid, Blotter, acid, Doses, Dots, Trips, Mellow Yellow, Window Pane, as well as names that reflect the designs on sheets of blotter paper (for example, "purple dragon").
What is LSD?
LSD (lysergic acid diethylamide), first synthesized in 1938, is an extremely potent hallucinogen. It is synthetically made from lysergic acid, which is found in ergot, a fungus that grows on rye and other grains. It is so potent its doses tend to be in the microgram range. It's effects, often called a "trip" can be stimulating, pleasurable, and mind-altering or it can lead to n unpleasant, sometimes terrifying experience called a "bad trip."
In the U.S., LSD is illegal and is classified by the Drug Enforcement Agency (DEA) as a Schedule 1 drug, meaning the LSD has a high potential for abuse, it has no currently accepted medical treatment use in the U.S., and it has a lack of accepted safety for use under medical supervision.
LSD is produced in crystalline form and then mixed with other inactive ingredients, or diluted as a liquid for production in ingestible forms. It is odorless, colorless and has a slightly bitter taste.
LSD is usually found on the streets in various forms, for example:
- blotter paper (LSD soaked onto sheets of absorbent paper with colorful designs; cut into small, individual dosage units) - the most common form.
- thin squares of gelatin (commonly referred to as window panes)
- tablet form (usually small tablets known as Microdots) or capsules
- liquid on sugar cubes
- pure liquid form (may be extremely potent)
Some people may inhale LSD through the nose (snort) or inject it into a vein (shoot it up). There is no way to predict the amount of LSD that might be in any form you consume.
Other hallucinogens include:
- Psilocybin (Magic Mushrooms, Shrooms)
- Mescaline (Peyote, Buttons, Cactus)
- Phencyclidine (PCP, Angel Dust)
- Ayahuasca (DMT)
- Salvia divinorum (salvia)
Effects of LSD Use
LSD is a mind-altering drug. It is thought LSD causes it's characteristic hallucinogenic effects via interaction with the serotonin receptors in the brain. Serotonin is a neurotransmitter that helps control your behavior and mood, governs your senses, and moderates you thoughts.
The physical effects of LSD are unpredictable from person-to-person, and no one knows if they will have a good or bad "trip." Usually, the first effects of the drug when taken by mouth are felt 30 to 45 minutes after taking it, peak at 2 to 4 hours, and may last 12 hours or longer. Use by the intravenous (IV) route will produce a much quicker action, usually within 10 minutes. Effects include:
- distorted visual perception of shapes, colors
- altered sounds
- anxiety and depression
- flashbacks (a return of the "trip" experience) days or months later
- rapid heart rate, increased body temperature and high blood pressure
- dilated pupils
Extreme changes in mood can occur. If taken in large enough doses, the drug produces delusions and visual hallucinations. Overdose can lead to severe psychosis. Death is often due to a direct injury while under LSD influence; there is no known lethal dose of LSD.
The physical effects can also include nausea, loss of appetite, increased blood sugar, difficulty sleeping, dry mouth, tremors and seizures.
The user may also experience impaired depth and time perception, with distorted perception of the size and shape of objects, movements, color, sound, touch and own body image. Sensations may seem to "cross over," giving the feeling of hearing colors and seeing sounds. These changes can be frightening and can cause panic. Some LSD users also experience severe, terrifying thoughts and feelings, fear of losing control, fear of insanity and death.
An experience with LSD is referred to as a "trip" and acute, disturbing psychological effects as a "bad trip". These experiences are lengthy, with the effects of higher doses lasting for 6 to 12 hours, and it may take 24 hours to return to a normal state.
Health Hazards and Flashbacks with LSD
Under the influence of LSD, the ability to make sensible judgments and see common dangers is impaired, making the user susceptible to personal injury, which can be fatal.
After an LSD trip, the user may suffer acute anxiety or depression, and may also experience flashbacks (also called hallucinogen persisting perception disorder), which are recurrences of the effects of LSD days or even months after taking the last dose.
- A flashback occurs suddenly, often without warning, usually in people who use hallucinogens chronically or have an underlying personality problem.
- Healthy people who use LSD only occasionally may also have flashbacks.
- Bad trips and flashbacks are only part of the risks of LSD use. LSD users may also manifest relatively long-lasting psychoses, such as schizophrenia or severe depression.
LSD produces tolerance, meaning the user needs greater doses of LSD to get the same high. Some users who take the drug repeatedly must take progressively higher doses to achieve the state of intoxication that they had previously achieved. This is an extremely dangerous practice, given the unpredictability of the drug.
Extent of LSD Use
The National Survey on Drug Use and Health (NHSDA) in 2016 estimated that the percentage of the population aged 18 to 25 who had ever used LSD (the lifetime prevalence rate) was 8.3%, up from 7.7% in 2015. In those 12 and older, lifetime estimates were 9.6%, those ages 12 to 17 were 1.2%, and those older than 26 years was 10.8%. These last three estimates had held steady over the previous year.
Rates of LSD use remain low among youth in the U.S. Between the years 2015 to 2016, trends in annual prevalence of use of LSD for Grades 8, 10, and 12 combined were 1.9% (2015) and 2.0% (2016), a +0.1 points percentage increase. The Monitoring the Future National Survey Results on Drug Use: 2016 Overview. Key Findings on Adolescent Drug Use found that "generational forgetting" -- students stating that they are not familiar with the drug -- has resulted in a decline in perceived risk of LSD among younger groups, which may put them at higher risk of use in future years. This points to the need for continued education over time on all illicit drugs that may be a risk for youth.
Treatment for LSD Use
Once a decision is made to obtain treatment, there are several steps to take.
- Speak to a healthcare provider to help direct you to reliable sources of help and monitor your progress.
- Talk therapy (behavioral counseling) and/or group counseling may be an option to help you understand your behaviors and why you continue to use LSD.
- Keep your appointments and follow your providers treatment plan.
- Consider including trusted family or friends in your treatment plan.
- Take care of yourself: exercise, eat healthfully, and control your stress level. Surround yourself with supportive people.
- Added medical therapy may be needed to treat symptoms due to drug use, such as anxiety, depression, or schizophrenia.
- Work to find new hobbies and interests that will take your mind off of LSD. Consider a volunteer opportunity.
- Each day make an effort to stay away from people who abuse drugs, even if they are former friends.
- National Institute on Drug Abuse (NIDA). Patients & Families. Treatment Resources.
- What to Do If Your Teen or Young Adult Has a Problem with Drugs
- Partnership for Drug-Free Kids
- SAMHSA’s National Helpline – 1-800-662-HELP (4357)
- Bath Salts
- Devil's Breath
- Gray Death
- PCP (Phencyclidine)
- Psilocybin (Magic Mushrooms)
- Speed (methamphetamine)
- Synthetic Marijuana (Spice or K2)
- TCP (Tenocyclidine)
- U-47700 (Pink)
- Substance Abuse and Mental Health Services Administration, National Survey on Drug Use and Health: Trends in Prevalence of Various Drugs for Ages 12 or Older, Ages 12 to 17, Ages 18 to 25, and Ages 26 or Older; 2015 - 2016 (in percent). Accessed August 29, 2018 at https://www.drugabuse.gov/national-survey-drug-use-health
- LSD. U.S. Drug Enforcement Agency (DEA). Accessed August 30, 2018 at https://www.dea.gov/factsheets/lsd
- List of Schedule 1 Drugs. Drugs.com. Accessed August 30, 2018 https://www.drugs.com/article/csa-schedule-1.html
- How Widespread Is the Abuse of Hallucinogens and Dissociative Drugs? National Institute on Drug Abuse (NIDA). Accessed August 29, 2018 at https://www.drugabuse.gov/publications/research-reports/hallucinogens-dissociative-drugs/why-do-people-take-hallucinogens
- Hallucinogens and Dissociative Drugs. From the Director. National Institute on Drug Abuse (NIDA). Accessed August 29, 2018 at https://www.drugabuse.gov/publications/research-reports/hallucinogens-dissociative-drugs/director
- Substance use - LSD. MedLine Plus. U.S. National Library of Medicine. Accessed August 30, 2018 at https://medlineplus.gov/ency/patientinstructions/000795.htm
- LSD Overdose. Drugabuse.com. Accessed August 30, 2018 at https://drugabuse.com/library/lsd-overdose/
- Johnston L, O'Malley P, Miech R, et al. Monitoring the Future National Survey Results on Drug Use: 2016 Overview. Key Findings on Adolescent Drug Use. The University of Michigan Institute for Social Research. Accessed August 31, 2018 at http://monitoringthefuture.org//pubs/monographs/mtf-overview2016.pdf
- LSD. NZ Drug Foundation. Accessed August 30, 2018 at https://www.drugfoundation.org.nz/info/drug-index/lsd/
- Psychedelic Amazonian Drug, Ayahuasca, Might Ease Symptoms of Depression, Alcoholism. Drugs.com. Nov. 14, 2017. Accessed August 31, 2018 at https://www.drugs.com/news/psychedelic-amazonian-ayahuasca-might-ease-depression-alcoholism-67741.html
- Hallucinogens. National Institute on Drug Abuse (NIDA). Accessed August 29, 2018 at https://www.drugabuse.gov/publications/drugfacts/hallucinogens
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.