Nexavar and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Nexavar (sorafenib).
Sorafenib Food/Lifestyle
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food may reduce the oral absorption and bioavailability of sorafenib. According to the product labeling, sorafenib bioavailability was reduced by 29% when administered with a high-fat meal compared to administration in the fasted state. When given with a moderate-fat meal, bioavailability was similar to that in the fasted state.
MANAGEMENT: To ensure maximal and consistent oral absorption, sorafenib should be taken at least one hour before or two hours after eating.
References (1)
- (2005) "Product Information. Nexavar (sorafenib)." Bayer Pharmaceutical Inc
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Nexavar drug interactions
There are 436 drug interactions with Nexavar (sorafenib).
Nexavar disease interactions
There is 1 disease interaction with Nexavar (sorafenib) which include:
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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