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Prednisolone and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with prednisolone.

Moderate

High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

corticosteroids - fluid retention

Corticosteroids may cause hypernatremia, hypokalemia, fluid retention, and elevation in blood pressure. These mineralocorticoid effects are most significant with fludrocortisone, followed by hydrocortisone and cortisone, then by prednisone and prednisolone. The remaining corticosteroids, betamethasone, dexamethasone, methylprednisolone, and triamcinolone, have little mineralocorticoid activities. However, large doses of any corticosteroid can demonstrate these effects, particularly if given for longer than brief periods. Therapy with corticosteroids should be administered cautiously in patients with preexisting fluid retention, hypertension, congestive heart failure, and/or renal dysfunction. Dietary sodium restriction and potassium supplementation may be advisable.

References

  1. "Product Information. Hydeltrasol (prednisolone)." Merck & Co., Inc (2001):
  2. "Product Information. Deltasone (prednisone)." Pharmacia and Upjohn (2001):
  3. "Product Information. Decadron (dexamethasone)." Merck & Co., Inc (2001):
  4. "Product Information. Hydrocortone (hydrocortisone)." Merck & Co., Inc (2001):
  5. "Product Information. Medrol (methylprednisolone)." Pharmacia and Upjohn (2001):
  6. "Product Information. Florinef Acetate (fludrocortisone)." Bristol-Myers Squibb (2001):
  7. "Product Information. Cortone Acetate (cortisone)." Merck & Co., Inc (2001):
  8. "Product Information. Kenalog (triamcinolone)." Bristol-Myers Squibb (2001):
  9. "Product Information. Celestone (betamethasone)." Schering Corporation (2001):
  10. "Product Information. Emflaza (deflazacort)." PTC Therapeutics, Inc. (2021):
View all 10 references
Moderate

High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)

Moderate Potential Hazard, Moderate plausibility

corticosteroids - hyperlipidemia

Corticosteroids may elevate serum triglyceride and LDL cholesterol levels if used for longer than brief periods. Patients with preexisting hyperlipidemia may require closer monitoring during prolonged corticosteroid therapy, and adjustments made accordingly in their lipid-lowering regimen.

References

  1. Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42
  2. "Product Information. Hydeltrasol (prednisolone)." Merck & Co., Inc (2001):
  3. "Product Information. Deltasone (prednisone)." Pharmacia and Upjohn (2001):
  4. "Product Information. Decadron (dexamethasone)." Merck & Co., Inc (2001):
  5. "Product Information. Hydrocortone (hydrocortisone)." Merck & Co., Inc (2001):
  6. "Product Information. Medrol (methylprednisolone)." Pharmacia and Upjohn (2001):
  7. "Product Information. Florinef Acetate (fludrocortisone)." Bristol-Myers Squibb (2001):
  8. "Product Information. Cortone Acetate (cortisone)." Merck & Co., Inc (2001):
  9. "Product Information. Kenalog (triamcinolone)." Bristol-Myers Squibb (2001):
  10. "Product Information. Celestone (betamethasone)." Schering Corporation (2001):
View all 10 references

Prednisolone drug interactions

There are 555 drug interactions with prednisolone.

Prednisolone disease interactions

There are 23 disease interactions with prednisolone which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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