Naloxone/pentazocine and Alcohol/Food Interactions

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Alcohol may potentiate the central nervous system (CNS) depressant effects of opioid analgesics including pentazocine. Concomitant use may result in additive CNS depression and impairment of judgment, thinking, and psychomotor skills. In more severe cases, hypotension, respiratory depression, profound sedation, coma, or even death may occur.

MONITOR CLOSELY: Smoking tobacco may decrease the plasma concentrations and effects of pentazocine by enhancing its metabolic clearance.

MANAGEMENT: Patients should not consume alcoholic beverages or use drug products that contain alcohol during treatment with pentazocine. Any history of alcohol or illicit drug use should be considered when prescribing pentazocine and therapy initiated at a lower dosage if necessary. Patients should be closely monitored for signs and symptoms of sedation, respiratory depression, and hypotension. Additionally, the possibility of reduced therapeutic effects of pentazocine should be considered if smoking cannot be avoided.