Mephobarbital and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with mephobarbital.
Mephobarbital Alcohol (Ethanol)
Major Drug Interaction
GENERALLY AVOID: Concurrent acute use of barbiturates and ethanol may result in additive CNS effects, including impaired coordination, sedation, and death. Tolerance of these agents may occur with chronic use. The mechanism is related to inhibition of microsomal enzymes acutely and induction of hepatic microsomal enzymes chronically.
MANAGEMENT: The combination of ethanol and barbiturates should be avoided.
References (5)
- Gupta RC, Kofoed J (1966) "Toxological statistics for barbiturates, other sedatives, and tranquilizers in Ontario: a 10-year survey." Can Med Assoc J, 94, p. 863-5
- Misra PS, Lefevre A, Ishii H, Rubin E, Lieber CS (1971) "Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats." Am J Med, 51, p. 346-51
- Saario I, Linnoila M (1976) "Effect of subacute treatment with hypnotics, alone or in combination with alcohol, on psychomotor skills related to driving." Acta Pharmacol Toxicol (Copenh), 38, p. 382-92
- Stead AH, Moffat AC (1983) "Quantification of the interaction between barbiturates and alcohol and interpretation of fatal blood concentrations." Hum Toxicol, 2, p. 5-14
- Seixas FA (1979) "Drug/alcohol interactions: avert potential dangers." Geriatrics, 34, p. 89-102
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Mephobarbital drug interactions
There are 570 drug interactions with mephobarbital.
Mephobarbital disease interactions
There are 13 disease interactions with mephobarbital which include:
- acute alcohol intoxication
- drug dependence
- liver disease
- porphyria
- rash
- respiratory depression
- renal dysfunction
- suicidal tendency
- adrenal insufficiency
- depression
- hematologic toxicity
- osteomalacia
- paradoxical reactions
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More about mephobarbital
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- Reviews (4)
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- Side effects
- Dosage information
- During pregnancy
- Drug class: barbiturate anticonvulsants
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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