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Liothyronine and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with liothyronine.


liothyronine multivitamins with minerals

Moderate Drug Interaction

Using multivitamin with minerals together with liothyronine may decrease the effects of liothyronine. You should separate the administration of liothyronine and multivitamin with minerals by at least 4 hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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High Blood Pressure (Hypertension)

Major Potential Hazard, High plausibility

thyroid hormones - cardiovascular disease

Thyroid hormones cause increases in myocardial contractility and heart rate as a result of increased metabolic demands and oxygen consumption. Therapy with thyroid hormones should be administered cautiously and initiated at reduced dosages in patients with cardiovascular disorders such as angina, coronary artery disease, and hypertension. Clinical monitoring of cardiovascular function is recommended. If chest pain or exacerbation of cardiovascular disease occurs, the dosage of thyroid hormone should be reduced, even at the expense of achieving euthyroid state. Thyroid hormones should not be administered to patients with an acute myocardial infarction that is not complicated by hypothyroidism.


  1. "Product Information. Synthroid (levothyroxine)." Abbott Pharmaceutical (2002):
  2. "Product Information. Cytomel (liothyronine)." Monarch Pharmaceuticals Inc (2001):
  3. "Product Information. Armour Thyroid (thyroid desiccated)." Forest Pharmaceuticals (2022):
  4. "Product Information. Thyrolar (liotrix)." Forest Pharmaceuticals (2001):
View all 4 references

Liothyronine drug interactions

There are 193 drug interactions with liothyronine.

Liothyronine disease interactions

There are 5 disease interactions with liothyronine which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.