Ztalmy and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Ztalmy (ganaxolone).
Ganaxolone Food/Lifestyle
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of ganaxolone. When administered with a high-fat meal, ganaxolone peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 3- and 2-fold, respectively, compared to administration under fasted conditions. Ganaxolone was administered with food in the premarketing study population. The efficacy of ganaxolone when administered in the fasted state is unknown.
GENERALLY AVOID: Concomitant use of ganaxolone with central nervous system (CNS) depressants, including alcohol, may potentiate adverse effects such as somnolence and sedation.
MANAGEMENT: Ganaxolone must be administered with food according to the manufacturer. Patients should be advised to avoid or limit consumption of alcohol and to avoid activities requiring mental alertness such as driving or operating hazardous machinery until they know how the medication affects them.
References (1)
- (2022) "Product Information. Ztalmy (ganaxolone)." Marinus Pharmaceuticals, Inc
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Ztalmy drug interactions
There are 413 drug interactions with Ztalmy (ganaxolone).
Ztalmy disease interactions
There are 4 disease interactions with Ztalmy (ganaxolone) which include:
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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