Estramustine and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with estramustine.
Estramustine Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food and milk may significantly decrease serum concentrations of estramustine. The mechanism of the interaction is not known.
MANAGEMENT: It is recommended that estramustine be taken at least 1 hour before or 2 hours after meals, and that it not be coadministered with milk, or calcium containing products.
References (1)
- (2001) "Product Information. Emcyt (estramustine)." Pharmacia and Upjohn
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Estramustine High Blood Pressure (Hypertension)
Major Potential Hazard, High plausibility
estramustine - hypertension
The risk of myocardial infarction and strokes, including those associated with estrogen use, may be increased in patients with hypertension. Moreover, estramustine may elevate blood pressure and worsen the hypertension, thus compounding the risk. Therapy with estramustine should be administered cautiously in patients with preexisting hypertension. Patients should be monitored for changes in cardiovascular status, and their antihypertensive regimen adjusted as necessary.
References (6)
- Crane MG, Harris JJ (1978) "Estrogens and hypertension: effect of discontinuing estrogens on blood pressure, exchangeable sodium, and the renin-aldosterone system." Am J Med Sci, 276, p. 33-55
- Crane MG, Harris JJ, Winsor W 3d (1971) "Hypertension, oral contraceptive agents, and conjugated estrogens." Ann Intern Med, 74, p. 13-21
- Rosenberg L, Slone D, Shapiro S, Kaufman D, Stolley PD, Miettinen OS (1980) "Noncontraceptive estrogens and myocardial infarction in young women." JAMA, 244, p. 339-42
- Jick H, Dinan B, Rothman KJ (1978) "Noncontraceptive estrogens and nonfatal myocardial infarction." JAMA, 239, p. 1407-8
- Wren BG, Routledge DA (1981) "Blood pressure changes: oestrogens in climacteric women." Med J Aust, 2, p. 528-31
- (2001) "Product Information. Emcyt (estramustine)." Pharmacia and Upjohn
Switch to consumer interaction data
Estramustine drug interactions
There are 138 drug interactions with estramustine.
Estramustine disease interactions
There are 9 disease interactions with estramustine which include:
- hypertension
- thromboembolism/cardiovascular
- abnormal vaginal bleeding
- hypercalcemia in breast cancer
- hypercalcemia
- liver disease
- fluid retention
- glucose intolerance
- thyroid function tests
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More about estramustine
- estramustine consumer information
- Check interactions
- Compare alternatives
- Reviews (1)
- Side effects
- Dosage information
- During pregnancy
- Drug class: hormones/antineoplastics
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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