Zytiga and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Zytiga (abiraterone).
Abiraterone Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food may significantly increase the oral bioavailability of some formulations of abiraterone acetate. Compared to administration in the fasted state, abiraterone peak plasma concentration (Cmax) and systemic exposure (AUC) were approximately 7- and 5-fold higher, respectively, when a single dose of abiraterone acetate was administered with a low-fat meal (7% fat; 300 calories) and approximately 17- and 10-fold higher, respectively, when it was administered with a high-fat meal (57% fat; 825 calories). Given the normal variation in the content and composition of meals, taking abiraterone acetate with meals has the potential to result in increased and highly variable exposures. The safety of these increased exposures during multiple dosing has not been assessed. However, the abiraterone acetate 125 mg tablet, commonly marketed as Yonsa, was found to have an approximately 6.5-fold higher Cmax and 4.4-fold higher AUC when a single dose of 500 mg (4 tablets) was administered with a high-fat meal (56% - 60% fat, 900 - 1000 calories) compared to overnight fasting in healthy volunteers. These differences were not considered clinically significant for this formulation.
MANAGEMENT: Some formulations of abiraterone acetate must be taken on an empty stomach. No food should be consumed for at least two hours before and one hour after the abiraterone acetate dose. However, the abiraterone acetate 125 mg tablet, commonly marketed as Yonsa, can be taken with or without food. The manufacturer's product labeling should be consulted for specific guidance.
References
- (2011) "Product Information. Zytiga (abiraterone)." Centocor Inc
- (2023) "Product Information. Akeega (abiraterone-niraparib)." Janssen Biotech, Inc.
- (2023) "Product Information. Akeega (abiraterone-niraparib)." Janssen Inc
- (2021) "Product Information. Zytiga (abiraterone)." Janssen Biotech, Inc.
- (2022) "Product Information. Yonsa (abiraterone)." Sun Pharmaceutical Industries
- (2023) "Product Information. Apo-Abiraterone (abiraterone)." Apotex Inc
- (2021) "Product Information. Zytiga (abiraterone)." Janssen-Cilag Pty Ltd
- (2023) "Product Information. Abiraterone (abiraterone)." Wockhardt UK Ltd
- (2023) "Product Information. Yonsa Mpred (abiraterone-methylprednisolone)." Sun Pharma ANZ Pty Ltd
Zytiga drug interactions
There are 408 drug interactions with Zytiga (abiraterone).
Zytiga disease interactions
There are 2 disease interactions with Zytiga (abiraterone) which include:
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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